SAB4301170
Anti-pan-AKT antibody produced in rabbit
affinity isolated antibody
Synonym(s):
PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
56 kDa
species reactivity
rat, human, mouse
concentration
2 mg/mL
technique(s)
western blot: 1:500-1:1000 (Cell Lysate)
isotype
IgG
accession no.
NP_001014431.1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... AKT1(207)
Related Categories
General description
AKT serine/threonine kinase 1 (AKT1) also called as v-akt murine thymoma viral oncogene homolog 1 or protein kinase B α (PKB α) is encoded by the gene mapped to human chromosome 14q32. It is highly expressed in liver, muscle and adipocytes. The encoded protein is a member of AKT family, which is characterized with an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain.
Specificity
The antibody detects endogenous levels of total pan-AKT protein.
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human RAC-alpha serine/threonine-protein kinase
Application
Anti-pan-AKT antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
AKT serine/threonine kinase 1 (AKT1) acts as a regulator for cell-survival and anti-apoptotic actions which are involved in development of various cancers. This protein has a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development. Mutations in the gene are associated with the pathogenesis of prostate cancer (PC). Elevated expression of the gene has been observed in human gastric cancer. Aberrations in the AKT1 and glycogen synthase kinase 3 (GSK3)-β signaling leads to the development of schizophrenia.
Features and Benefits
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Physical form
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice.
Cho H, et al.
The Journal of Biological Chemistry, 276, 38349-38352 (2001)
Tctex1d2 Is a Negative Regulator of GLUT4 Translocation and Glucose Uptake
Shimoda Y, et al.
Endocrinology, 156, 3548-3558 (2015)
Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population.
Liu JM, et al.
Genetics and molecular research : GMR, 16 (2017)
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.
Emamian ES, et al.
Nature Genetics, 36, 131-137 (2004)
Noriyasu Kamei et al.
Scientific reports, 8(1), 17641-17641 (2018-12-07)
In a recent study, we demonstrated the potential of a cell-penetrating peptide (CPP) penetratin to deliver the peptide drug insulin to the brain via nasal administration, and its pharmacological effect on the mild cognitive dysfunction in senescence-accelerated mouse (SAMP8). However
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