SAB4300468
Anti-PTK2B (Ab-402) antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
Anti-CADTK antibody produced in rabbit, Anti-CAKB antibody produced in rabbit, Anti-FADK2 antibody produced in rabbit, Anti-FAK2 antibody produced in rabbit, Anti-PTK2B protein tyrosine kinase 2 beta antibody produced in rabbit
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~116 kDa
species reactivity
rat, mouse, human
concentration
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(D-I-Y-A-E)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PTK2B(2185)
General description
PTK2B/ Pyk2 (proline-rich tyrosine kinase 2β) is a non receptor protein kinase that belongs to the focal adhesion kinase family. It is also known as FAK2 (focal adhesion kinase 2), RAFTK (related adhesion focal tyrosine kinase) and CAKB (cell adhesion kinase beta). Its expression is confined to the endothelium, central nervous system and hematopoietic lineages. It is located on human chromosome 8p21.1.
Immunogen
Peptide sequence around aa. 400-404 (D-I-Y-A-E), according to the protein PTK2B.
Application
Anti-PTK2B (Ab-402) antibody has been used in immunohistofluorescence.
Biochem/physiol Actions
Protein tyrosine kinase 2β(PTK2B) participates in the pathogenesis of Alzheimer′s disease (AD). It induces tumor progression in multiple myeloma. It helps in the multiplication, movement and survival of cells.
Features and Benefits
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Target description
Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
A Dual Role for the Nonreceptor Tyrosine Kinase Pyk2 during the Intracellular Trafficking of Human Papillomavirus 16
Gottschalk EY and Meneses PI
Journal of Virology, 89(17), 9103-9114 (2015)
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology
Dourlen P, et al.
Molecular Psychiatry, 22(6), 874-883 (2017)
Whole-genome association studies of alcoholism with loci linked to schizophrenia susceptibility
Namkung J, et al.
BMC Genetics, 6 (2005)
Common variant in PTK2B is associated with late-onset Alzheimer's disease: A replication study and meta-analyses
Li YQ, et al.
Neuroscience Letters, 621, 83-87 (2016)
P Dourlen et al.
Molecular psychiatry, 22(6), 874-883 (2016-04-27)
A recent genome-wide association meta-analysis for Alzheimer's disease (AD) identified 19 risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila, we screened 296 constructs targeting orthologs of 54 candidate risk genes within these loci
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