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SAB2900091

Sigma-Aldrich

Anti-SLC7A11 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

CCBR1, amino acid transport system xc-, calcium channel blocker resistance protein 1, cystine/glutamate transporter, solute carrier family 7 member 11

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

UniProt accession no.

Q9UPY5

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SLC7A11(23657)

General description

Solute carrier family 7, membrane 11 (SLC7A11), a constituent of the cysteine-glutamate transporter, is located on human chromosome 4q28.31. It belongs to the system xc- light chain family. SLC7A11 gene codes for the cystine-glutamate antiporter Xct.

Immunogen

Synthetic 19 amino acid peptide from N-terminus of human SLC7A11. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Monkey, Marmoset (95%); Horse (89%); Rat, Dog, Hamster (84%).

Application

Anti-SLC7A11 antibody has been used in western blot analysis.

Biochem/physiol Actions

Solute carrier family 7, membrane 11 (SLC7A11) or xCT participates in glutathione homeostasis, that helps to guard the cells against oxidative stress. It is involved in the pathogenesis of malignant tumors. SLC7A11 is associated with triple negative breast cancer and glioblastoma (GBM).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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MiR?375/SLC7A11 axis regulates oral squamous cell carcinoma proliferation and invasion.
Wu Y, et al.
Cancer Medicine, 6(7), 1686-1697 (2017)
mTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT
Yuchao G, et al.
Molecular Cell, 67(1), 128?138-128?138 (2017)
SLC7A11, a component of cysteine/glutamate transporter, is a novel biomarker for the diagnosis and prognosis in laryngeal squamous cell carcinoma.
Ma Z, et al.
Oncology Reports, 38(5), 3019-3029 (2017)
Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer.
Yajun L, et al.
Oncotarget, 8(68), 112530?112549-112530?112549 (2017)
Yadong Wu et al.
Cancer medicine, 6(7), 1686-1697 (2017-06-20)
We aimed to detect the functions of miR-375/SLC7A11 axis on oral squamous cell carcinoma (OSCC) cell proliferation and invasion. Expression levels of miR-375 and SLC7A11 in OSCC tissues and cells were measured with RT-qPCR and western blot. Targeting site was

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