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Sigma-Aldrich

SYBR® Green JumpStart Taq ReadyMix for High Throughput qPCR

SYBR® Green qPCR reagent, passive reference dye included

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About This Item

UNSPSC Code:
41106300
NACRES:
NA.55

Quality Level

form

liquid

usage

sufficient for 20 reactions
sufficient for 2000 reactions
sufficient for 400 reactions

feature

dNTPs included
hotstart

concentration

1.25 units/reaction (50 μL reaction volume)

technique(s)

qPCR: suitable

color

colorless

input

purified DNA

compatibility

for use with ABI 5700
for use with ABI 7000
for use with ABI 7300
for use with ABI 7700
for use with ABI 7900 Fast
for use with ABI 7900 HT
for use with ABI 7900
for use with ABI StepOne
for use with ABI StepOnePlus

detection method

SYBR® Green

shipped in

wet ice

storage temp.

−20°C

Related Categories

General description

SYBR® Green JumpStart Taq ReadyMix is a ready-to-use 2X master mix that contains SYBR® Green I, JumpStart Taq DNA polymerase, 99% pure deoxynucleotides (dNTPs), and reaction buffer making it the ideal solution for performing high-throughput quantitative PCR. SYBR® Green I dye binds to and detects any dsDNA generated during amplification. The JumpStart Taq DNA polymerase is an antibody-inactivated hot-start enzyme. Once the reaction temperature reaches 70°C, the DNA polymerase-antibody complex dissociates and Taq DNA polymerase activity is restored. This antibody-enzyme complex allows for easy and convenient set-up with less contamination risk than manual hot-start techniques.

Application

SYBR® Green JumpStart Taq ReadyMix for High Throughput qPCR has been used for the amplification and quantification of transcripts to analyze gene expression in 2-step quantitative reverse transcription PCR (RT-qPCR). It has also been used for quantitative polymerase chain reaction (qPCR) of reverse-transcribed cDNA.

Features and Benefits

  • The master mix allows consistency and reproducibility from one reaction to the next
  • Reduced set-up time as compared to manual or wax Hot Start methods
  • Reduced primer dimers
  • Allows for room temperature set-up; Ideal for high throughput, quantitative PCR application
  • SYBR® Green I dye binds to double-stranded DNA and is ideal for quantifying any DNA sequence. Detection is monitored by measuring the increase in fluorescence throughout cycling.
  • JumpStart Taq DNA polymerase prevents amplification of non-specific products while increasing target yield.
  • Internal Reference Dye is provided for reaction normalization. Maximum excitation and emission is 586 nm and 605 nm, respectively.
  • SYBR Green JumpStart Taq ReadyMix reduces preparation time and the risk of contamination from multiple pipetting steps.

Packaging

Default reaction volume is 50 μL

20RXN is packaged as 1 X 500 μL
400RXN is packaged as 1 X 10 mL
2000RXN is packaged as 1 X 50 mL

Other Notes

SYBR Green ReadyMix for High Throughput Quantitative PCR combines the performance enhancements of JumpStart Taq and SYBR Green I in an easy-to-use ReadyMix solution that incorporates ROX dye for ABI and other real time instrument applications. The ReadyMix includes a detection fluor, internal standard and reagents for PCR making it the ideal solution for performing high-throughput quantitative PCR.

Legal Information

Use of this product is covered by one or more of the following US patents and corresponding patent claims outside the US: 5,994,056 and 6,171,785.. The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser′s own internal research. No right under any other patent claim (such as apparatus or system claims in US Patent No. 6,814,934) and no right to perform commercial services of any kind, including without limitation reporting the results of purchaser′s activities for a fee or other commercial consideration, is conveyed expressly, by implication, or by estoppel. This product is for research use only. Diagnostic uses under Roche patents require a separate license from Roche. Further information on purchasing licenses may be obtained by contacting the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA.
JumpStart is a trademark of Sigma-Aldrich Co. LLC
ReadyMix is a trademark of Sigma-Aldrich Co. LLC
SYBR is a registered trademark of Life Technologies

Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Regulatory Information

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Extraordinary transgressive phenotypes of hybrid tomato are influenced by epigenetics and small silencing RNAs
<BIG><BIG>Shivaprasad PV, et al.</BIG></BIG>
The Embo Journal, 31, 257-266 (2012)
Extraordinary transgressive phenotypes of hybrid tomato are influenced by epigenetics and small silencing RNAs
Shivaprasad PV, et al.
The Embo Journal, 31(2), 257-266 (2012)
Muscle-specific and age-related changes in protein synthesis and protein degradation in response to hindlimb unloading in rats
Baehr LM, et al.
Journal of Applied Physiology, 122(5), 1336-1350 (2017)
Distribution of HPV Genotypes in Patients with a Diagnosis of Anal Cancer in an Italian Region
<BIG><BIG>Muresu N, et al.</BIG></BIG>
International Journal of Environmental Research and Public Health, 17, 4516-4516 (2020)
Gene resistance to transcriptional reprogramming following nuclear transfer is directly mediated by multiple chromatin-repressive pathways
Jullien J, et al.
Molecular Cell, 65(5), 873-884 (2017)

Articles

qPCR investigates gene expression, amplification, and alterations, crucial for tumor biology and understanding cancer genetics.

The polymerase chain reaction is one of the most widely used techniques in molecular biology. The PCR process consists of three main steps, Denaturation, Annealing & Extension

Protocols

A protocol that can be used as a basic template for qPCR incorporating SYBR Green I DNA binding dye that is amenable to modification and applicable for use as validation for a set of primers.

Our SYBR Green qPCR Protocol is a method designed to detect accurate quantification of gene expression and RT-PCR reactions

Related Content

SYBR® Green I, a commonly used fluorescent DNA binding dye, binds all double-stranded DNA and detection is monitored by measuring the increase in fluorescence throughout the cycle. Explore our LuminoCt® and KiCqStart® products for Fast qPCR or JumpStart™ reagents for conventional qPCR

RT-qPCR detects specific targets with applications in gene expression and pathogen detection.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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