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S8626

Sigma-Aldrich

Sulfadiazine

99.0-101.0%

Synonym(s):

4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide

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12 UNITS
¥1,072.68

¥1,072.68

Estimated to ship on2025年6月03日Details

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12 UNITS
¥1,072.68

About This Item

Empirical Formula (Hill Notation):
C10H10N4O2S
CAS Number:
68-35-9
Molecular Weight:
250.28
Beilstein:
6733588
EC Number:
200-685-8
MDL number:
MFCD00006065
UNSPSC Code:
51283908
PubChem Substance ID:
24899802
NACRES:
NA.85

¥1,072.68

Estimated to ship on2025年6月03日Details

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description

Solubility - Practically insoluble in water, slightly soluble in acetone, very slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and in dilute mineral acids.

Quality Level

200

Assay

99.0-101.0%

form

powder or crystals

color

white to faint yellow, faint pink

mp

253 °C (dec.) (lit.)

solubility

96% ethanol: very slightly soluble
acetone: slightly soluble
water: practically insoluble

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

Mode of action

DNA synthesis | interferes
enzyme | inhibits

SMILES string

Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2

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Show Differences

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This Item
13191013192095299
过氧化氢 溶液 34.5-36.5%

18304

过氧化氢 溶液

过氧化氢 溶液 JIS special grade, 30.0-35.5%

131910

过氧化氢 溶液

过氧化氢 溶液 SAJ first grade, ≥30.0%

131920

过氧化氢 溶液

过氧化氢 溶液 purum p.a., ≥35% (RT)

95299

过氧化氢 溶液

assay

34.5-36.5%

assay

-

assay

-

assay

≥35% (RT)

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

100

solubility

diethyl ether: soluble, water: soluble, petroleum ether: insoluble

solubility

-

solubility

-

solubility

-

reaction suitability

reagent type: oxidant

reaction suitability

reagent type: oxidant

reaction suitability

reagent type: oxidant

reaction suitability

reagent type: oxidant

density

1.130 g/cm3

density

1.13 g/cm3

density

1.13 g/cm3

density

1.13 g/mL at 20 °C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

2-8°C

General description

Chemical structure: sulfonamide

Application

Sulfadiazine is a short-acting sulfonamide that is commonly used with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome. It is also used to treat newborns with congenital infections[1]. Sulfadiazine has been used to control acute infections when studying murine models of reactivated toxoplasmosis[2].

Biochem/physiol Actions

Sulfadiazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

Signal Word

Warning

Hazard Statements

H302,H361d,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Sven Jechalke et al.
    Applied and environmental microbiology, 79(5), 1704-1711 (2013-01-15)
    Spreading manure containing antibiotics in agriculture is assumed to stimulate the dissemination of antibiotic resistance in soil bacterial populations. Plant roots influencing the soil environment and its microflora by exudation of growth substrates might considerably increase this effect. In this
    Romain Sonneville et al.
    Neurology, 79(17), 1762-1766 (2012-10-12)
    Cerebral toxoplasmosis remains a common neurologic complication in patients with AIDS. In this study, we aimed to characterize the prognosis of patients with HIV infection with severe forms of cerebral toxoplasmosis and to investigate the effects of adjunctive steroids on
    Tamim M Niazi et al.
    International journal of radiation oncology, biology, physics, 84(3), e305-e310 (2012-06-02)
    For patients with anal canal and advanced rectal cancer, chemoradiation therapy is a curative modality or an important adjunct to surgery. Nearly all patients treated with chemoradiation experience some degree of radiation-induced dermatitis (RID). Prevention and effective treatment of RID
    Ildiko R Dunay et al.
    Antimicrobial agents and chemotherapy, 53(10), 4450-4456 (2009-07-29)
    Immunocompromised patients are at risk of developing toxoplasmosis, and although chemotherapy is available, standard treatments are often complicated by severe side effects. Artemisinin is a new highly potent antimalarial drug that has activity against Toxoplasma gondii in vitro. However, artemisinin
    Pascale Meneceur et al.
    Antimicrobial agents and chemotherapy, 52(4), 1269-1277 (2008-01-24)
    Sulfadiazine, pyrimethamine, and atovaquone are widely used for the treatment of severe toxoplasmosis. Their in vitro activities have been almost exclusively demonstrated on laboratory strains belonging to genotype I. We determined the in vitro activities of these drugs against 17
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