S5447
Anti-SIRT1 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-S. cerevisiae, HOMOLOG-LIKE 1, Anti-SIR2, Anti-SIR2α, Anti-SIR2L1, Anti-Sirtuin 1
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1 EA
¥6,780.43
About This Item
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~120 kDa
species reactivity
human
concentration
~1.0 mg/mL
1 of 4
This Item | 852081 | 852288 | 852347 |
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| functional group sulfonic acid | functional group Fmoc | functional group Fmoc | functional group sulfonic acid |
| product line Novabiochem® | product line Novabiochem® | product line Novabiochem® | product line Novabiochem® |
| storage temp. 15-25°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. -10 to -25°C |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis |
General description
Anti-SIRT1 recognizes human SIRT1. Sirtuin 1 (SIRT1) is encoded by the gene mapped to human chromosome 10q21.3. The encoded protein belongs to the silent information regulator (SIR) family and is a class of HDAC (histone deacetylase). SIRT1 is expressed in various tissues including brain, liver, pancreas, adipose tissue, and skeletal muscle. SIRT1 is also known as the longevity gene.
Immunogen
synthetic peptide corresponding to amino acids 580-593 of human SIRT1, conjugated to KLH via an N-terminal cysteine residue. The corresponding sequence differs by three amino acids in rat and mouse Sirt1.
Application
Anti-SIRT1 antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions
Sirtuin 1 (SIRT1) functions as a regulator of various metabolic pathways, and influences the pathophysiology of several metabolic diseases. It is a regulator of protein deacetylation, and is a candidate therapeutic target in non-alcoholic fatty liver disease (NAFLD), amyotrophic lateral sclerosis (ALS), kidney disease, and pulmonary disease. It also participates in tumorigenesis, and whether it functions as an oncogene or as a tumor suppressor depends upon the tumor type. In pancreatic ductal adenocarcinoma (PDAC), its elevated expression is linked with poor prognosis, and in non-small-cell lung cancer (NSCLC), it suppresses the expression of tumor suppressor p27. The encoded protein inhibits the terminal differentiation in dividing myocytes by binding to the myoD cofactor, pCAF. It is also thought to function as a suppressor of cardiovascular disorders, such as myocardial infarction, or neurodegenerative diseases, such as Alzheimer′s disease (AD) or Parkinson′s disorder (PD).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frostfree” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Other Notes
In order to obtain the best results using various techniques and preparations, we recommend determining the optimal working dilutions by titration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Mammalian SIRT1 Represses Forkhead Transcription Factors
Motta MC, et al.
Cell, 116, 551-563 (2004)
17?-Estradiol Attenuates Hematoma Expansion through ERa/Sirt1/NF-?B Pathway in Hyperglycemic Intracerebral Hemorrhage Mice
Zheng Y, et al.
Stroke, 46, 485?491-485?491 (2015)
Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1.
Voelter-Mahlknecht S and Mahlknecht U
International Journal of Molecular Medicine, 17, 59-67 (2006)
Diana J Liu et al.
Journal of cellular physiology, 229(9), 1224-1235 (2014-01-18)
Neurons have a limited capacity for heat shock protein (HSP) induction and are vulnerable to the pathogenic consequence of protein misfolding and aggregation as seen in age-related neurodegenerative diseases. Sirtuin 1 (SIRT1), an NAD(+) -dependent lysine deacetylase with important biological
[SIRT1].
Hattori Y and Ihara M
Nihon Rinsho. Japanese Journal of Clinical Medicine (2016)
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