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Safety Information

P7962

Sigma-Aldrich

Monoclonal Anti-PSTAIR antibody produced in mouse

clone PSTAIR, ascites fluid

Synonym(s):

Anti-CDC2

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100 μL
CN¥5,187.66
0.2 ML
CN¥6,922.02

CN¥5,187.66

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100 μL
CN¥5,187.66
0.2 ML
CN¥6,922.02

About This Item

MDL number:
MFCD00677382
UNSPSC Code:
12352203
NACRES:
NA.43

CN¥5,187.66

Please contact Customer Service for Availability
Request a Bulk Order

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

PSTAIR, monoclonal

mol wt

antigen 33-34 kDa

contains

15 mM sodium azide

species reactivity

mouse, Japanese quail, human, amago salmon, eel, starfish, lily, carp, onion, goldfish, monkey, Xenopus, ciliates

technique(s)

immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1:4,000 using a COS-7 cell extract

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This Item
C7464C8218C4710
Monoclonal Anti-PSTAIR antibody produced in mouse clone PSTAIR, ascites fluid

P7962

Monoclonal Anti-PSTAIR antibody produced in mouse

Monoclonal Anti-Cyclin D1 antibody produced in mouse clone DCS-6, ascites fluid

C7464

Monoclonal Anti-Cyclin D1 antibody produced in mouse

Monoclonal Anti-Cdk4 antibody produced in mouse clone DCS-31, ascites fluid

C8218

Monoclonal Anti-Cdk4 antibody produced in mouse

Monoclonal Anti-Cyclin A antibody produced in mouse clone CY-A1, ascites fluid

C4710

Monoclonal Anti-Cyclin A antibody produced in mouse

clone

PSTAIR, monoclonal

clone

DCS-6, monoclonal

clone

DCS-31, monoclonal

clone

CY-A1, monoclonal

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... CDC2(983)
mouse ... Cdc2a(12534)

Gene Information

human ... CCND1(595)
mouse ... Ccnd1(12443)
rat ... Ccnd1(58919)

Gene Information

human ... CDK4(1019)
mouse ... Cdk4(12567)
rat ... Cdk4(94201)

Gene Information

human ... CCNA2(890)
mouse ... Ccna2(12428)

species reactivity

mouse, Japanese quail, human, amago salmon, eel, starfish, lily, carp, onion, goldfish, monkey, Xenopus, ciliates

species reactivity

rat, mouse, human, monkey

species reactivity

rat, mouse, human

species reactivity

mouse, human, monkey, bovine

General description

In every eukaryote examined, CDKs contain an evolutionary conserved 16 amino acid sequence called PSTAIR (EGVPSTAIREISLLKE) which distinguishes them from other protein kinases. The PSTAIR motif is involved in complex formation with cyclins. The availability of monoclonal antibody reacting specifically with the PSTAIR sequence enables the subcellular detection and localization of the various CDKs and examination of substrate interactions, in a variety of organisms.
Monoclonal Anti-PSTAIR (mouse IgG1 isotype) is derived from the PSTAIR hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Cyclin-dependent kinase 1 (CDC2/CDK1) belongs to the Ser/Thr protein kinase family. It is located on human chromosome 10q21.

Immunogen

synthetic 16 amino acid oligopeptide containing the PSTAIR sequence conjugated to BSA.

Application

Monoclonal Anti-PSTAIR antibody produced in mouse has been used in:
  • western blot analysis
  • enzyme-linked immunosorbent assay (ELISA)
  • immunoprecipitation

Mouse monoclonal clone PSTAIR anti-PSTAIR antibody may be used for the localization of cyclin-dependent kinases containing the PSTAIR motif using various immunochemical assays including ELISA, immunoblot and immunoprecipitation.

Biochem/physiol Actions

Cyclin-dependent kinase 1 (CDC2/CDK1) controls various mitotic processes including the reorganization of the cytoskeleton, chromosome segregation, and formation and separation of daughter cells. It is essential for the multiplication of mammalian cell. It participates in tumorigenesis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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    Lot/Batch Number
    0000395458
    0000335148
    0000395458
    0000335148
    0000130472

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    Molecular Cancer, 10(1), 23-23 (2011)
    Marta A Garbacz et al.
    Nature communications, 9(1), 858-858 (2018-03-01)
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    Jing Xue et al.
    Cell research, 27(12), 1503-1520 (2017-11-22)
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    Inoue H, et al.
    Nucleic Acids Research (2019)
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