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Key Documents

Safety Information

P6374

Sigma-Aldrich

p53 human

recombinant, expressed in baculovirus infected Sf21 cells

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20 EA
CN¥3,850.41

CN¥3,850.41

Available to ship onApril 27, 2025Details

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20 EA
CN¥3,850.41

About This Item

UNSPSC Code:
12352202
NACRES:
NA.25

CN¥3,850.41

Available to ship onApril 27, 2025Details

Request a Bulk Order

biological source

human

Quality Level

200

recombinant

expressed in baculovirus infected Sf21 cells

Assay

≥90% (SDS-PAGE)

form

aqueous solution

technique(s)

dot blot: suitable

UniProt accession no.

P04637

application(s)

genomic analysis

shipped in

dry ice

storage temp.

−70°C

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Show Differences

1 of 4

This Item
853086853001852164
Boc-Trp-OH Novabiochem®

853038

Boc-Trp-OH

Boc-D-Trp-OH Novabiochem®

853086

Boc-D-Trp-OH

Boc-Ala-OH Novabiochem®

853001

Boc-Ala-OH

Fmoc-D-Trp(Boc)-OH Novabiochem®

852164

Fmoc-D-Trp(Boc)-OH

form

powder

form

powder

form

powder

form

powder

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥85.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

15-25°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

General description

p53 protein is composed of an N-terminal domain with a transactivation domain and proline-rich region, a central core-DNA binding domain, and a C-terminal domain with tetramerization and regulatory domains.[1] The TP53 gene which encodes for the p53 protein is mapped on the human chromosome at 17p13.1.[2]

Application

Useful for the study of postranslational modification of p53, or protein-protein interaction studies.
p53 human has been used in dot blot.[3]

Biochem/physiol Actions

In addition, p53 was recently shown to induce differentiation of human embryonic stem cells. The effect is dependent on the DNA binding activity of p53. [4]
p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.
p53 protein acts as a transcription factor that participates in regulating positively or negatively the expression of several responsive genes. It plays a role in regulating angiogenesis, cellular senescence, autophagy, cell survival, differentiation, and oxidative stress. Mutations in the TP53 gene lead to Li Fraumeni cancer syndrome.[5]

Physical properties

Histidine-tagged, full length human p53

Physical form

Supplied as a solution in 20 mM Tris-HCl, pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA, and 1 mM DTT.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000308088
    0000308088
    SLCP0771
    SLCQ2309
    SLCN6491

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    Fiamma Mantovani et al.
    Cell death and differentiation, 26(2), 199-212 (2018-12-13)
    Forty years of research have established that the p53 tumor suppressor provides a major barrier to neoplastic transformation and tumor progression by its unique ability to act as an extremely sensitive collector of stress inputs, and to coordinate a complex
    p53: structure, function and therapeutic applications
    Bai L and Zhu W
    Journal of Cancer Molecules, 2(4), 141-153 (2006)
    Adam Shlien et al.
    American journal of human genetics, 87(5), 631-642 (2010-11-09)
    DNA copy-number variations (CNVs) underlie many neuropsychiatric conditions, but they have been less studied in cancer. We report the association of a 17p13.1 CNV, childhood-onset developmental delay (DD), and cancer. Through a screen of over 4000 patients with diverse diagnoses
    Abhinav K Jain et al.
    PLoS biology, 10(2), e1001268-e1001268 (2012-03-06)
    Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this is strictly due to repression of proliferation remains a subject of debate. Here, we show that p53 plays an active role in promoting differentiation of human
    Karen H Vousden et al.
    Nature reviews. Molecular cell biology, 8(4), 275-283 (2007-03-24)
    As a component of the response to acute stress, p53 has a well established role in protecting against cancer development. However, it is now becoming clear that p53 can have a much broader role and can contribute to the development
    View All Related Papers

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