SAB4500003
Anti-BCL-2 antibody produced in rabbit
affinity isolated antibody
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All Photos(3)
Synonym(s):
Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, BCL2
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 26 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BCL2(596)
General description
B-cell lymphoma 2 (BCL-2) is an integral inner mitochondrial membrane protein that acts as an antiapoptotic protein. It is a target gene of nuclear factor kappa B (NF-kB). The gene encoding BCL-2 is localized on human chromosome 18q21.
Immunogen
The antiserum was produced against synthesized peptide derived from human BCL-2.
Immunogen Range: 46-95
Immunogen Range: 46-95
Application
Anti-BCL-2 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
BCL2 is an apoptosis regulator that is expressed in sub-cellular components such as the mitochondria and nucleus. While mitochondrial BCL2 inhibits apoptosis, BCL2 present in the nucleus may activate cell death. BCL2 may also regulate autophagy during starvation . Anti-BCL-2 antibodies are specific for endogenous levels of total BCL-2 protein in rats, humans and mice.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Bcl-2 is a critical mediator of intestinal transformation.
Heijden M, et al.
Nature Communications (2016)
Different signalling in infarcted and non-infarcted areas of rat failing hearts: A role of necroptosis and inflammation
Lichy M, et al.
Journal of Cellular and Molecular Medicine (2019)
Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.
Portier BP
The Journal of Biological Chemistry (2006)
Xuan-Pei Xu et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 22(1), 58-64 (2020-01-18)
To study the effect and mechanism of action of irisin on hypoxic-ischemic brain damage in neonatal rats. A total of 248 7-day-old Sprague-Dawley rats were randomly divided into a sham-operation group, a model group, and low- and high-dose irisin intervention
Martin Lichý et al.
Journal of cellular and molecular medicine, 23(9), 6429-6441 (2019-07-23)
Necroptosis has been recognized in heart failure (HF). In this study, we investigated detailed necroptotic signalling in infarcted and non-infarcted areas separately and its mechanistic link with main features of HF. Post-infarction HF in rats was induced by left coronary
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