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Safety Information

P126

Sigma-Aldrich

Pirenperone

>97%, solid

Synonym(s):

3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2-methyl-4H-pyrido-[1,2-a] pyrimidin-4-one, R-47,465

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About This Item

Empirical Formula (Hill Notation):
C23H24FN3O2
CAS Number:
75444-65-4
Molecular Weight:
393.45
EC Number:
278-213-5
MDL number:
MFCD00069332
UNSPSC Code:
12352200
PubChem Substance ID:
24278110

Quality Level

200

Assay

>97%

form

solid

color

light yellow

solubility

0.1 M HCl: 11 mg/mL
methanol: 2.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 5.0 mg/mL

SMILES string

CC1=C(CCN2CCC(CC2)C(=O)c3ccc(F)cc3)C(=O)N4C=CC=CC4=N1

InChI

1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3

InChI key

HXCNRYXBZNHDNE-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Biochem/physiol Actions

5-HT2 serotonin receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
048H4736

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K A Cunningham et al.
The Journal of pharmacology and experimental therapeutics, 241(1), 147-151 (1987-04-01)
Although the discriminative stimulus effects of the clinically useful ergot derivative lisuride have previously been related to dopamine (DA) neuronal systems, the involvement of DA D1 and D2 receptor subtypes in the lisuride cue has been characterized for the first
J C Winter et al.
Pharmacology, biochemistry, and behavior, 62(3), 543-547 (1999-03-18)
Stimulus control was established in a group of nine rats using a dose of EGb 761 of 10 mg/kg, administered i.p., 15 min before training. A two-lever operant task using a fixed-ratio 10 schedule of sweetened milk reinforcement was used.
L A Dykstra et al.
Psychopharmacology, 112(1), 116-120 (1993-01-01)
The kappa opioid, U50,488, was examined alone and in combination with the 5HT2 antagonists, ketanserin, pirenperone and LY 53857. Squirrel monkeys responded under a shock titration procedure in which shock intensity increased every 15 s from 0.01 to 2.0 mA
H J Altman et al.
Pharmacology, biochemistry, and behavior, 28(3), 353-359 (1987-11-01)
The experiments examined the effects of acute administration of three different serotonergic receptor antagonists (ketanserin, pirenperone and mianserin) on one-trial passive avoidance retention in mice. Administration of each antagonist 30 min before training produced a dose-dependent impairment in retention. In
B Le Grand et al.
Journal of cardiovascular pharmacology, 26(5), 803-809 (1995-11-01)
Action potential duration (APD) lengthening is believed to underlie the cardiac arrhythmogenicity of ketanserin, a serotonin (5-HT)2A/2C receptor antagonist. We wished to determine (a) whether this activity involves blockade of 5-HT2A/2C receptors and (b) the precise mechanism of ketanserin-induced APD
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