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P126

Sigma-Aldrich

Pirenperone

>97%, solid

Synonym(s):

3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2-methyl-4H-pyrido-[1,2-a] pyrimidin-4-one, R-47,465

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About This Item

Empirical Formula (Hill Notation):
C23H24FN3O2
CAS Number:
75444-65-4
Molecular Weight:
393.45
EC Number:
278-213-5
MDL number:
MFCD00069332
UNSPSC Code:
12352200
PubChem Substance ID:
24278110
To inquire about this product P126, please contact your local Merck office or dealer. Contact Technical Service

Quality Level

200

Assay

>97%

form

solid

color

light yellow

solubility

0.1 M HCl: 11 mg/mL
methanol: 2.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 5.0 mg/mL

SMILES string

CC1=C(CCN2CCC(CC2)C(=O)c3ccc(F)cc3)C(=O)N4C=CC=CC4=N1

InChI

1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3

InChI key

HXCNRYXBZNHDNE-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

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Show Differences

1 of 4

This Item
S7395D5919T6154
Pirenperone >97%, solid

P126

Pirenperone

Spiperone solid

S7395

Spiperone

Diacylglycerol Kinase Inhibitor I solid

D5919

Diacylglycerol Kinase Inhibitor I

Trazodone hydrochloride ≥99% (HPLC), powder

T6154

Trazodone hydrochloride

form

solid

form

solid

form

solid

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

solubility

0.1 M HCl: 11 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 5.0 mg/mL, methanol: 2.5 mg/mL

solubility

H2O: slightly soluble 0.2 mg/mL, 0.1 M HCl: slightly soluble 0.3 mg/mL, ethanol: 1.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2 mg/mL

solubility

0.1 M HCl: slightly soluble, 0.1 M NaOH: slightly soluble, DMSO: soluble, H2O: insoluble, ethanol: soluble, ethyl acetate: soluble

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 23.3 mg/mL, methanol: soluble 25 mg/mL, clear, colorless, 0.1 M HCl: soluble 7.4 mg/mL, DMSO: soluble, H2O: soluble, hazy, colorless

color

light yellow

color

light yellow

color

pale yellow

color

-

Gene Information

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

Gene Information

human ... ADRA1B(147), DRD2(1813), DRD3(1814), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356)
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413), Adra2a(25083), Drd1a(24316), Drd2(24318), Drd3(29238), Htr1a(24473), Htr2a(29595), Htr2c(25187), Htr7(65032)

Gene Information

-

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2C(3358), SLC6A4(6532)

Biochem/physiol Actions

5-HT2 serotonin receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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    Lot/Batch Number
    048H4736

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    K A Cunningham et al.
    The Journal of pharmacology and experimental therapeutics, 241(1), 147-151 (1987-04-01)
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    G Griebel et al.
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    The mouse defense test battery (MDTB) has been designed to investigate defensive reactions in Swiss-Webster mice to situations associated with a natural predator, the rat, such as flight, avoidance, defensive threat, defensive attack, and risk assessment activities. The present study
    M J Walker et al.
    Psychopharmacology, 113(3-4), 527-533 (1994-01-01)
    Several studies have demonstrated a paradoxical form of antinociception induced by the repeated administration of opioid antagonists accompanied by exposure to a painful stimulus. The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several
    C Goodrich et al.
    Physiology & behavior, 46(2), 203-209 (1989-08-01)
    Experiments were designed to distinguish between central and peripheral effects on temperature preference and body temperature of drugs injected intraperitoneally (IP) in infant mice ranging in age from 3 to 10 days postpartum. These compared a drug restricted to the
    L A Dykstra et al.
    Psychopharmacology, 112(1), 116-120 (1993-01-01)
    The kappa opioid, U50,488, was examined alone and in combination with the 5HT2 antagonists, ketanserin, pirenperone and LY 53857. Squirrel monkeys responded under a shock titration procedure in which shock intensity increased every 15 s from 0.01 to 2.0 mA
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