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P0042

Sigma-Aldrich

PP2

≥98% (HPLC)

Synonym(s):

4-Amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine, AG 1879

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5 MG
CN¥2,443.96

CN¥2,443.96

Available to ship onApril 11, 2025Details

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5 MG
CN¥2,443.96

About This Item

Empirical Formula (Hill Notation):
C15H16ClN5
CAS Number:
172889-27-9
Molecular Weight:
301.77
MDL number:
MFCD01568210
UNSPSC Code:
12352200
PubChem Substance ID:
329819994
NACRES:
NA.77

CN¥2,443.96

Available to ship onApril 11, 2025Details

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

CC(C)(C)n1nc(-c2ccc(Cl)cc2)c3c(N)ncnc13

InChI

1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)

InChI key

PBBRWFOVCUAONR-UHFFFAOYSA-N

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This Item
P0040P0037P0036
PP2 ≥98% (HPLC)

P0042

PP2

PP1 ≥98% (HPLC)

P0040

PP1

PP242 hydrate ≥98% (HPLC), powder

P0037

PP242 hydrate

PP121 ≥98% (HPLC)

P0036

PP121

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >10 mg/mL

solubility

DMSO: >20 mg/mL

solubility

DMSO: >10 mg/mL

solubility

DMSO: >10 mg/mL

color

white to off-white

color

white to off-white

color

off-white

color

off-white

Application

PP2 has been used:
  • to analyze the effects of Src/focal adhesion kinase (FAK) signaling on IQ domain GTPase-activating protein 1 (IQGAP1)-mediated anoikis resistance[1]
  • for Src inhibition to study its effect on epidermal growth factor receptor (EGFR) and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation in non-small cell lung cancer (NSCLC) cells[2]
  • for pharmacological inhibition of SRC in MDA-MB-231 breast cancer cells[3]

Biochem/physiol Actions

PP2 is a selective inhibitor of Src-family tyrosine kinases of non-receptor tyrosine kinases (nRTK). It shows >10,000-fold selectivity over Zeta-chain-associated protein kinase 70 (ZAP-70) and Janus kinase 2 (JAK2). PP2 effectively reduces cervical cancer proliferation in vitro and in vivo.[4]

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000328877
    0000328877
    0000102489
    0000149393
    0000149393

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    Mika Soma et al.
    Frontiers in neuroscience, 12, 282-282 (2018-05-17)
    Dendritic spine is a small membranous protrusion from a neuron's dendrite that typically receives input from an axon terminal at the synapse. Memories are stored in synapses which consist of spines and presynapses. Rapid modulations of dendritic spines induced by
    Miharu Shida et al.
    Biochimica et biophysica acta. General subjects, 1863(9), 1319-1331 (2019-06-11)
    Chondroitin sulfate (CS) chains are prominent extra/pericellular matrix components in the central nervous system (CNS) and can exert positive or negative regulatory effects on neurite outgrowth, depending on the CS structure and the amount. Despite the remarkable abilities of highly
    Fabio Cattaneo et al.
    Phytochemical analysis : PCA, 30(5), 524-534 (2019-06-07)
    Sempervivum tectorum L. (Crassulaceae), is a succulent perennial plant widespread in Mediterranean countries and commonly used in traditional medicine for ear inflammation, ulcers and skin rashes as a refrigerant and astringent. To demonstrate the therapeutic effects of the plant, various
    Chunxing Zheng et al.
    Proceedings of the National Academy of Sciences of the United States of America, 112(52), E7239-E7248 (2015-12-17)
    Obesity-associated inflammation is accompanied by the accumulation of adipose tissue macrophages (ATMs), which is believed to predispose obese individuals to insulin resistance. CD11b (integrin αM) is highly expressed on monocytes and macrophages and is critical for their migration and function.
    Ruchi Jain et al.
    European journal of cell biology, 95(12), 623-634 (2016-11-23)
    Histamine, a primary mediator of allergic responses, elicits its effects by activating specific receptors belonging to the GPCR family in target cells. Activation of histamine receptor can activate MAP kinases as recorded by monitoring the phosphorylation of extracellular signal regulated
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