Skip to Content
Merck
CN

P0037

PP242 hydrate

≥98% (HPLC), powder

Synonym(s):

2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C16H16N6O · xH2O
CAS Number:
1173019-76-5
Molecular Weight:
308.34 (anhydrous basis)
MDL number:
MFCD12828866
UNSPSC Code:
12352200
PubChem Substance ID:
329819988
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

O.CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c4c(N)ncnc14

InChI

1S/C16H16N6O.H2O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12;/h3-8,20,23H,1-2H3,(H2,17,18,19);1H2

InChI key

FMDOLJSFPXFBIL-UHFFFAOYSA-N

Related Categories

Application

PP242 hydrate has been used:
  • as a mammalian target of rapamycin (mTOR) inhibitor to study its effects on rat fibroblast mTOR complex 1 and 2 (mTORC1 & 2) signaling
  • as an mTOR inhibitor to treat mouse embryonic fibroblasts (MEF) and cumulus cells (CCs) to study its effects on reactivation of embryonic nucleoli and ribosome biogenesis
  • as a target of rapamycin (TOR) kinase inhibitor for the treatment of Arabidopsis to study its effects against Fusarium graminearum infection

Biochem/physiol Actions

PP242 is a potent and selective mTOR inhibitor.
PP242 is a potent and selective mTOR inhibitor. PP242 is a first selective inhibitor that targets ATP domain of mTOR.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000283679
0000223490
0000019100
0000223490
0000019100

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Transient inhibition of rDNA transcription in donor cells improves ribosome biogenesis and preimplantation development of embryos derived from somatic cell nuclear transfer
Liao C, et al.
Faseb Journal, 26(12), 2774-2789 (2020)
TOR signaling downregulation increases resistance to the cereal killer Fusarium graminearum
Aznar N, et al.
Plant signaling & behavior, 13(2), e1414120-e1414120 (2018)
Fibroblast mTOR/PPAR$ gamma/ HGF axis protects against tubular cell death and acute kidney injury
Gui Y, et al
Cell Death and Differentiation, 26(12), 2774-2789 (2019)
Eleftherios Karanasios et al.
Current protocols in cytometry, 69, 12-12 (2014-07-06)
Autophagy is a membrane-trafficking pathway activated to deliver cytosolic material for degradation to lysosomes through a novel membrane compartment, the autophagosome. Fluorescence microscopy is the most common method used to visualize proteins inside cells, and it is widely used in
Néstor R Aznar et al.
Plant signaling & behavior, 13(2), e1414120-e1414120 (2017-12-12)
TOR is the master regulator of growth and development that senses energy availability. Biotic stress perturbs metabolic and energy homeostasis, making TOR a good candidate to participate in the plant response. Fusarium graminearum (Fusarium) produces important losses in many crops
View All Related Papers

Articles

PKB/Akt

We offer many products related to PKB/Akt for your research needs.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service