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Merck
CN

N194

NS-398

≥98% (HPLC), solid

Synonym(s):

N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C13H18N2O5S
CAS Number:
123653-11-2
Molecular Weight:
314.36
MDL number:
MFCD00882995
UNSPSC Code:
12352200
PubChem Substance ID:
24897540
NACRES:
NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

off-white

mp

127-128 °C

solubility

DMSO: >5 mg/mL
H2O: insoluble

SMILES string

CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O

InChI

1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3

InChI key

KTDZCOWXCWUPEO-UHFFFAOYSA-N

Gene Information

human ... ALOX5(240), CYP19A1(1588), PTGS1(5742), PTGS2(5743)
mouse ... Ptgs2(19225)

Related Categories

Application

NS-398 has been used as a cyclooxygenase-2 (COX2) inhibitor to study its effects on:
  • the cardiac rate in zebrafish embryos
  • apoptosis and hypoxia/reoxygenation in rat cardiomyocytes
  • the lipopolysaccharide (LPS) induced anorexia in rats

Biochem/physiol Actions

NS-398 belongs to the non-steroidal anti-inflammatory drug (NSAID) family. It exhibits anti-inflammatory, analgesic, and anti-pyretic properties.
Selective cyclooxygenase-2 (COX-2) inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000143800
0000143800
091M4603V
0000143799
0000143799

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Jihye Jung et al.
Cells, 8(7) (2019-06-30)
The epithelial-mesenchymal transition (EMT) is important in organ fibrosis. We hypothesized that growth arrest-specific protein 6 (Gas6) and its underlying mechanisms play roles in the prevention of EMT in alveolar epithelial cells (ECs). In this study, to determine whether Gas6
N Futaki et al.
General pharmacology, 24(1), 105-110 (1993-01-01)
1. NS-398 (N-[2-cyclohexyloxy-4-nitrophenyl] methanesulfonamide) is a new non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. 2. The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac.
Yuyin Yi et al.
Placenta, 68, 44-51 (2018-07-30)
Enhanced expression and activity of cyclooxygenase-2 (COX-2) has been reported in trophoblasts from women with preeclampsia compared with healthy pregnant women. Prostaglandin E2, the production of which is initiated by COX-2, and transforming growth factor-β1 (TGF-β1) have been shown to
Pedro Cruz Duarte et al.
Experimental neurology, 234(2), 466-481 (2012-02-09)
Brain-derived neurotrophic factor (BDNF) exists in small to medium size neurons in adult rat dorsal root ganglion (DRG) and serves as a modulator at the first synapse of the pain transmission pathway in the spinal dorsal horn. Peripheral nerve injury
P Leclerc et al.
Scandinavian journal of immunology, 77(5), 350-360 (2013-03-16)
PGE2 is a potent lipid mediator of pain and oedema found elevated in RA. Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal enzyme of the PGE2 pathway inducible by proinflammatory cytokines. mPGES-1 is markedly upregulated in RA synovial tissue despite
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