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M6690

Sigma-Aldrich

MDL 28170

≥90% (TLC)

Synonym(s):

Calpain Inhibitor III

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50 EA
CN¥4,855.76

CN¥4,855.76

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50 EA
CN¥4,855.76

About This Item

Empirical Formula (Hill Notation):
C22H26N2O4
CAS Number:
88191-84-8
Molecular Weight:
382.45
MDL number:
MFCD00798796
UNSPSC Code:
12352200
PubChem Substance ID:
24278565
NACRES:
NA.77

CN¥4,855.76

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

200

Assay

≥90% (TLC)

composition

Peptide Content, >90%

solubility

DMSO: 26 mg/mL
H2O: insoluble
methanol: soluble

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C

InChI

1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1

InChI key

NGBKFLTYGSREKK-ANYOKISRSA-N

Gene Information

human ... CAPN1(823) , CAPN2(824)

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Show Differences

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Anti- Twist antibody produced in rabbit

SAB5701071

Anti- Twist antibody produced in rabbit

Anti-TWIST1 antibody produced in rabbit purified immunoglobulin, buffered aqueous solution

SAB1411370

Anti-TWIST1 antibody produced in rabbit

Anti-TWIST1 antibody produced in mouse purified immunoglobulin, buffered aqueous solution

SAB1406563

Anti-TWIST1 antibody produced in mouse

Monoclonal Anti-TWIST1 antibody produced in mouse clone 2G12, purified immunoglobulin, buffered aqueous solution

SAB1409776

Monoclonal Anti-TWIST1 antibody produced in mouse

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

mouse

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

technique(s)

immunohistochemistry: 1:50-1:200, western blot: 1:500-1:2000

technique(s)

western blot: 1 μg/mL

technique(s)

indirect immunofluorescence: suitable, western blot: 1 μg/mL

technique(s)

immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

species reactivity

mouse, rat, human

species reactivity

human

species reactivity

human

species reactivity

human

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

2G12, monoclonal

Amino Acid Sequence

Z-Val-Phe-al

Application

MDL 28170 has been used as a calpain inhibitor:
  • to study its effects on neuroinflammation and necroptosis in rat model of cardiac arrest[1]
  • to analyze its effects on the degradation of neuronal nitric oxide synthase (nNOS) in beef semimembranosus muscle[2]
  • to study its protective effects against traumatic brain injury and survival of bone marrow-derived mesenchymal stem cells (BMSCs) in rat brain[3]

Biochem/physiol Actions

MDL 28170 exhibits neuroprotective effects against spinal cord injury, focal cerebral ischemia, and neonatal hypoxia-ischemia in rats.[4] It also shows anti-inflammatory and anti-neurodegenerative properties.[3] MDL 28170 crosses the blood-brain barrier and penetrates readily through the cell membranes.[1]
MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H2O2 and A23187 treated PC12 cells. γ-secretase-inhibitor.
Potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL8337
BCCK4707
BCCH1187
BCCF4734
BCCD6068

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Jiangnan Hu et al.
Stem cell research & therapy, 10(1), 96-96 (2019-03-17)
Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number of transplanted BMSCs remains a pertinent challenge and can be attributed to the unfavorable microenvironment of the injured brain.
Wen-Yan Wang et al.
International immunopharmacology, 93, 107377-107377 (2021-02-01)
Cerebral ischemia-reperfusion injury (CIRI) is the leading cause of poor neurological prognosis after cardiopulmonary resuscitation (CPR). We previously reported that the extracellular signal-regulated kinase (ERK) activation mediates CIRI. Here, we explored the potential ERK/calpain-2 pathway role in CIRI using a
Lorelei B Silverman-Gavrila et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(5), 1975-1990 (2013-02-01)
Low-frequency depression (LFD) of transmitter release occurs at phasic synapses with stimulation at 0.2 Hz in both isolated crayfish (Procambarus clarkii) neuromuscular junction (NMJ) preparations and in intact animals. LFD is regulated by presynaptic activity of the Ca(2+)-dependent phosphatase calcineurin
Stephanie N Thompson et al.
Journal of neurotrauma, 27(12), 2233-2243 (2010-09-30)
The cytoskeletal and neuronal protective effects of early treatment with the blood-brain barrier- and cell-permeable calpain inhibitor MDL-28170 was examined in the controlled cortical impact (CCI) traumatic brain injury (TBI) model in male CF-1 mice. This was preceded by a
Mohammad A M Ali et al.
Biochemical and biophysical research communications, 423(1), 1-5 (2012-05-12)
Matrix metalloproteinase (MMP)-2 is a zinc-dependent endopeptidase which, alongside its known extracellular actions, plays fundamental roles in oxidative stress-induced injury to the heart. Intracellular cleavage targets of MMP-2 selectively mediating this injury include the sarcomeric proteins troponin I, myosin light
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