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M6690

MDL 28170

Name: MDL 28170
Brand: SIGMA

≥90% (TLC), calpain I and II inhibitor

Synonym(s):

Calpain Inhibitor III

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₆N₂O₄

CAS Number:

88191-84-8

Molecular Weight:

382.45

UNSPSC Code:

12352200

PubChem Substance ID:

24278565

NACRES:

NA.77

MDL number:

MFCD00798796

Assay:

≥90% (TLC)

Quality level:

200

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Properties

Product Name

MDL 28170, ≥90% (TLC)

Quality Level

200

assay

≥90% (TLC)

composition

Peptide Content, >90%

solubility

DMSO: 26 mg/mL, H₂O: insoluble, methanol: soluble

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C

InChI

1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1

InChI key

NGBKFLTYGSREKK-ANYOKISRSA-N

Gene Information

human ... CAPN1(823), CAPN2(824)

Description

Application

MDL 28170 has been used as a calpain inhibitor:

to study its effects on neuroinflammation and necroptosis in rat model of cardiac arrest
to analyze its effects on the degradation of neuronal nitric oxide synthase (nNOS) in beef semimembranosus muscle
to study its protective effects against traumatic brain injury and survival of bone marrow-derived mesenchymal stem cells (BMSCs) in rat brain

Biochem/physiol Actions

MDL 28170 exhibits neuroprotective effects against spinal cord injury, focal cerebral ischemia, and neonatal hypoxia-ischemia in rats. It also shows anti-inflammatory and anti-neurodegenerative properties. MDL 28170 crosses the blood-brain barrier and penetrates readily through the cell membranes.

MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H₂O₂ and A23187 treated PC12 cells. γ-secretase-inhibitor.

Potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury.

Jiangnan Hu et al.

Stem cell research & therapy, 10(1), 96-96 (2019-03-17)

Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number of transplanted BMSCs remains a pertinent challenge and can be attributed to the unfavorable microenvironment of the injured brain.

Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest.

Wen-Yan Wang et al.

International immunopharmacology, 93, 107377-107377 (2021-02-01)

Cerebral ischemia-reperfusion injury (CIRI) is the leading cause of poor neurological prognosis after cardiopulmonary resuscitation (CPR). We previously reported that the extracellular signal-regulated kinase (ERK) activation mediates CIRI. Here, we explored the potential ERK/calpain-2 pathway role in CIRI using a

Calcium, calpain, and calcineurin in low-frequency depression of transmitter release.

Lorelei B Silverman-Gavrila et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(5), 1975-1990 (2013-02-01)

Low-frequency depression (LFD) of transmitter release occurs at phasic synapses with stimulation at 0.2 Hz in both isolated crayfish (Procambarus clarkii) neuromuscular junction (NMJ) preparations and in intact animals. LFD is regulated by presynaptic activity of the Ca(2+)-dependent phosphatase calcineurin

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Global Trade Item Number

SKU	GTIN
M6690-25MG	04061834061168