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Safety Information

T1573

Sigma-Aldrich

Thrombin Receptor Activator Peptide 6

>95% (HPLC)

Synonym(s):

TRAP-6

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About This Item

Empirical Formula (Hill Notation):
C34H56N10O9
CAS Number:
141136-83-6
Molecular Weight:
748.87
MDL number:
MFCD00238172
UNSPSC Code:
12352200
PubChem Substance ID:
329826680
NACRES:
NA.77

Quality Level

200

Assay

>95% (HPLC)

form

lyophilized

technique(s)

cell culture | mammalian: suitable

solubility

0.1% TFA: soluble
water: soluble

UniProt accession no.

P25116

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

InChI

1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1

InChI key

HAGOWCONESKMDW-FRSCJGFNSA-N

Gene Information

human ... F2R(2149)

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn

General description

Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.

Application

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).

Biochem/physiol Actions

Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC50 = 0.8 μM).

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000278383
0000278383
0000177732
0000135681
0000135681

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Saskia Wand et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 24(1), 179-185 (2017-03-18)
We aimed to identify the prevalence of acetylsalicylic acid (ASA) nonresponse in patients after coronary artery bypass graft (CABG) surgery and the possible consequences for the rate of major cardiovascular events. This prospective, observational, bicentric cohort study was conducted in
Xavier Charest-Morin et al.
Frontiers in immunology, 9, 2183-2183 (2018-10-20)
Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from blood. We applied various forms of activation to fresh blood obtained from 10 healthy subjects or 10 patients with hereditary angioedema (HAE-1 or -2 only) to investigate kinin formation.
Chemistry and Biology of Serpins (2012)
JCAD, a gene at the 10p11 coronary artery disease locus, regulates Hippo signaling in endothelial cells
Jones PD, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(8), 1711-1722 (2018)
Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis
Johnson KE, et al.
Blood advances, 3(2), 198-211 (2019)
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