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Merck
CN

T1573

Thrombin Receptor Activator Peptide 6

>95% (HPLC)

Synonym(s):

TRAP-6

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About This Item

Empirical Formula (Hill Notation):
C34H56N10O9
CAS Number:
141136-83-6
Molecular Weight:
748.87
NACRES:
NA.77
PubChem Substance ID:
329826680
UNSPSC Code:
12352200
MDL number:
MFCD00238172

Key Documents

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Product Name

Thrombin Receptor Activator Peptide 6, >95% (HPLC)

solubility

water: soluble
0.1% TFA: soluble

InChI key

HAGOWCONESKMDW-FRSCJGFNSA-N

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

InChI

1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1

assay

>95% (HPLC)

form

lyophilized

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P25116

storage temp.

−20°C

Quality Level

200

Gene Information

human ... F2R(2149)

Biochem/physiol Actions

Hexapeptide fragment of the thrombin receptor (residues 42-47).
Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC50 = 0.8 μM).

General description

Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.

Other Notes

Lyophilized from 0.1% TFA in H2O

Application

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000430567
0000430567
0000278383
0000278383
0000177732

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Chemistry and Biology of Serpins (2012)
JCAD, a gene at the 10p11 coronary artery disease locus, regulates Hippo signaling in endothelial cells
Jones PD, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(8), 1711-1722 (2018)
Xavier Charest-Morin et al.
Frontiers in immunology, 9, 2183-2183 (2018-10-20)
Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from blood. We applied various forms of activation to fresh blood obtained from 10 healthy subjects or 10 patients with hereditary angioedema (HAE-1 or -2 only) to investigate kinin formation.
Juergen Koessler et al.
PloS one, 12(11), e0188193-e0188193 (2017-11-21)
Platelets are important for effective hemostasis and considered to be involved in pathophysiological processes, e.g. in cardiovascular diseases. Platelets provided for research or for therapeutic use are frequently separated from citrated whole blood (WB) stored for different periods of time.
Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis
Johnson KE, et al.
Blood advances, 3(2), 198-211 (2019)
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