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Safety Information

L3126

Sigma-Aldrich

Lipase from porcine pancreas

Type II, ≥125 units/mg protein (using olive oil (30 min incubation)), 30-90 units/mg protein (using triacetin)

Synonym(s):

Pancreatic lipase, PPL, Triacylglycerol acylhydrolase, Triacylglycerol lipase

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25 G
CN¥584.64
100 G
CN¥2,325.78
500 G
CN¥8,599.99
1 KG
CN¥14,419.49

CN¥584.64

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25 G
CN¥584.64
100 G
CN¥2,325.78
500 G
CN¥8,599.99
1 KG
CN¥14,419.49

About This Item

CAS Number:
9001-62-1
Enzyme Commission number:
3.1.1.3 (BRENDA, IUBMB)
EC Number:
232-619-9
MDL number:
MFCD00131509
UNSPSC Code:
12352204
NACRES:
NA.54

CN¥584.64

Available to ship onApril 27, 2025Details

Request a Bulk Order

biological source

Porcine pancreas

Quality Level

200

type

Type II

form

lyophilized (cake)

specific activity

≥125 units/mg protein (using olive oil (30 min incubation))
30-90 units/mg protein (using triacetin)

composition

protein, ≥20%

storage temp.

2-8°C

InChI

1S/C11H9N3O2.Na/c15-8-4-5-9(10(16)7-8)13-14-11-3-1-2-6-12-11;/h1-7,16H,(H,12,14);/q;+1/b13-9-;

InChI key

QWZUIMCIEOCSJF-CHHCPSLASA-N

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H8651

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assay

≥99.0%

assay

≥99.0% (titration)

assay

-

assay

≥99.0% (titration)

grade

BioPerformance Certified

grade

-

grade

-

grade

-

technique(s)

activity assay: suitable, cell culture | mammalian: suitable

technique(s)

HPLC: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

Quality Level

400

Quality Level

400

Quality Level

200

Quality Level

-

form

powder

form

powder

form

solution

form

powder

application(s)

cell analysis
diagnostic assay manufacturing
general analytical
life science and biopharma

application(s)

diagnostic assay manufacturing
general analytical (
)
life science and biopharma
metabolomics

application(s)

-

application(s)

diagnostic assay manufacturing

Application

Lipase from porcine pancreas has been used:
  • for the analysis of fatty acid at the 2-position of triglycerides.[1]
  • to determine the indigestible fraction of plant source that is resistant to the action of digestive enzymes.[2]
  • as a component of dissolution media to study the dissolution profiles of theophylline.[3]
Lipases are used industrially for the resolution of chiral compounds and the transesterification production of biodiesel.

Biochem/physiol Actions

Lipases catalyze the hydrolysis of esters in aqueous solutions and the synthesis of esters in non-aqueous solutions. They also produce hydroxyl and carboxylic groups through the hydrolysis of ester linkages in poly(ethylene terephthalate).

Lipases catalyze the hydrolysis of triacylglycerols into glycerol and free fatty acids.

Quality

Crude (Steapsin). Contains amylase and protease activity.

Unit Definition

One unit will hydrolyze 1.0 microequivalent of fatty acid from triacetin in 1 hr at pH 7.4 at 37°C. (pH 7.7 is used with olive oil as substrate)

Analysis Note

Protein determined by biuret.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H334

Precautionary Statements

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

动植物源性产品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000443202
    0000443202
    0000420307
    0000423879
    0000423878

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    M T Andonaegui et al.
    Drug development and industrial pharmacy, 25(11), 1199-1203 (1999-12-22)
    Dissolution profiles of theophylline (TP) from three types of sustained-release (SR) matrix tablets (plastic [PL], lipid [LP], and hydrophilic [HP]) in different dissolution media, with and without enzymes, were established. Also investigated was the influence of a treatment of the
    Peiliang Zhang et al.
    Journal of pharmaceutical and biomedical analysis, 174, 486-494 (2019-06-24)
    Natural compounds with diverse structural skeletons have different ionization efficiencies and different mass spectrometry (MS) responses. Some key factors influencing the electrostatic field induced spray ionization (EFISI)-MS for a variety of natural compounds have been optimized and improved. Fifteen reference
    Enzymatic transesterification of rapeseed oil and lauric acid in a continuous reactor.
    Forssell, P., et al.
    Journal of the American Oil Chemists' Society, 70, 1105-1109 (1993)
    The contribution of fruits and vegetables to dietary intake of polyphenols and antioxidant capacity in a Mexican rural diet: Importance of fruit and vegetable variety.
    Hervert-Hernandez D et al.
    Food Research International, 44, 1182-1189 (2011)
    Wijitrapha Ruangaram et al.
    Pharmaceuticals (Basel, Switzerland), 13(4) (2020-04-03)
    The prevalence of obesity is increasing globally. Despite the availability of a variety of anti-obesogenic drugs, including therapies under clinical development, these treatments are often indicated for patients with severe obesity, making them unsuitable for patients with mild obesity or
    View All Related Papers

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