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Safety Information

I2143

Sigma-Aldrich

Anti-Interleukin-6 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-IL-6

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About This Item

MDL number:
MFCD00162579
UNSPSC Code:
51111800
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

neutralization: suitable using human IL-6 in a T1165 cell proliferation bioassay
radioimmunoassay: suitable

UniProt accession no.

P05231

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This Item
SAB1400139WH0003569M1I7901
Anti-Interleukin-6 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution

I2143

Anti-Interleukin-6 antibody produced in rabbit

Anti-IL6 antibody produced in mouse IgG fraction of antiserum, buffered aqueous solution

SAB1400139

Anti-IL6 antibody produced in mouse

Monoclonal Anti-IL6 antibody produced in mouse clone 3E4, purified immunoglobulin, buffered aqueous solution

WH0003569M1

Monoclonal Anti-IL6 antibody produced in mouse

Monoclonal Anti-Interleukin-6 antibody produced in mouse clone 6708.11, purified immunoglobulin, lyophilized powder

I7901

Monoclonal Anti-Interleukin-6 antibody produced in mouse

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Anti-Interleukin 6 (IL-6) is produced in rabbit using purified human recombinant IL-6 produced in E. coli as the immunogen. Interleukin-6 is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. Interleukin-6 (IL-6) is a cytokine produced by activated T cells, endothelial cells, fibroblasts and activated monocytes or macrophages.

Specificity

The antibody will neutralize the biological activity of human IL-6 in cell culture. The antibody does not cross-react with human IL-1β, TNF-α or mouse IL-6.

Immunogen

Purified human recombinant IL-6 produced in E. coli.

Application

Anti-Interleukin-6 antibody can be used in western blotting and ELISA for studying human IL-6. It can also be used for dot blot immunoassay. Anti-Interleukin-6 antibody can be used for selective neutralization of human IL-6 bioactivity in cell culture. It can also be used in radioimmunoassay (RIA) (diluted 1:60,000).
It may also be used in immunoblotting.

Biochem/physiol Actions

Interleukin 6 (IL-6) acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells, and hepatocytes. Interleukin 6 (IL-6) also potentiates the proliferative effect of Interleukin 3 (IL-3) on multipotential hematopoietic progenitors.
Interleukin-6 (IL-6) is a cytokine produced by activated T cells, endothelial cells, fibroblasts and activated monocytes or macrophages. It plays a crucial role in regulating the acute phase response as well as responses occurs after injury and infection. It interacts with IL-2 and facilitates in the proliferation of T lymphocytes.

Physical form

Solution, 0.2 μm filtered, in 0.5 mL phosphate buffered saline, pH 7.4.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
0000119303
116M4855V
076M4822V
112M4846
100M4827

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Interleukin-6 and chronic inflammation
Gabay C, et al.
Arthritis Research & Therapy, 8(2), S3-S3 (2006)
Vuong Cat Khanh et al.
Stem cells and development, 29(21), 1382-1394 (2020-09-10)
Cancer metastasis is the leading cause of mortality among breast cancer patients. Type 2 diabetes mellitus (T2DM) has been suggested as a risk factor of breast cancer; however, whether or not T2DM is associated with breast tumor metastasis remains unclear.
Debra J Romberger et al.
American journal of physiology. Lung cellular and molecular physiology, 311(1), L101-L110 (2016-05-18)
Agricultural dust exposure results in significant lung inflammation, and individuals working in concentrated animal feeding operations (CAFOs) are at risk for chronic airway inflammatory diseases. Exposure of bronchial epithelial cells to aqueous extracts of hog CAFO dusts (HDE) leads to
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Yudkin J S, et al.
Atherosclerosis, 148(2), 209-214 (2000)
R P Nordan et al.
Science (New York, N.Y.), 233(4763), 566-569 (1986-08-01)
Plasmacytoma (PCT) cell lines dependent for proliferation and survival on a factor elaborated by the murine macrophage cell line, P388D1, were established in vitro. Adherent peritoneal cells induced by pristane produced 50-fold greater amounts of this activity in vitro than
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