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Merck
CN

D7909

Dicyclomine hydrochloride

≥99% (TLC), powder

Synonym(s):

2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride, [1,1-Bicyclohexyl]-1-carboxylic acid 2-(diethylamino)ethyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H35NO2 · HCl
CAS Number:
67-92-5
Molecular Weight:
345.95
NACRES:
NA.77
PubChem Substance ID:
24278385
UNSPSC Code:
41116107
EC Number:
200-671-1
MDL number:
MFCD00079158

Key Documents

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Product Name

Dicyclomine hydrochloride, ≥99% (TLC), powder

InChI key

GUBNMFJOJGDCEL-UHFFFAOYSA-N

InChI

1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H

SMILES string

CCN(CCOC(C1(C2CCCCC2)CCCCC1)=O)CC.[Cl]

assay

≥99% (TLC)

form

powder

color

off-white

solubility

H2O: 50 mg/mL

Quality Level

200

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

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Biochem/physiol Actions

Competitive muscarinic acetylcholine receptor antagonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000476397
0000459460
0000459460
0000476397
0000311404

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Najeeb-ur Rehman et al.
Phytotherapy research : PTR, 26(1), 136-141 (2011-10-19)
This study was aimed to provide the pharmacological basis for the medicinal use of Lepidium sativum in diarrhea using in vivo and in vitro assays. The seed extract of Lepidium sativum (Ls.Cr) at 100 and 300 mg/kg inhibited castor oil-induced diarrhea
P Grillner et al.
Neuroscience, 91(2), 557-565 (1999-06-12)
The effects of carbachol (0.01-30 microM) and muscarine (10-30 microM) on the excitatory synaptic potentials were studied using conventional intracellular recordings from dopaminergic neurons in rat mesencephalic slices. Both muscarinic agonists reversibly reduced the excitatory synaptic potentials, evoked by local
Larissa Zeggio Perez Figueredo et al.
Brain research bulletin, 77(2-3), 71-76 (2008-06-28)
A number of studies have suggested that the glutamatergic and cholinergic systems are both involved in learning and memory processes and that they interact in order to facilitate these processes. However, the role of M1-muscarinic receptors in mediating this interaction
Nav Persaud et al.
The International journal of risk & safety in medicine, 24(1), 31-35 (2012-03-23)
Until recently epidemiological evidence was not regarded as helpful in determining cause and effect. It generated associations that then had to be explained in terms of bio-mechanisms and applied to individual patients. A series of legal cases surrounding possible birth
Z W Jiang et al.
Brain research, 852(1), 37-44 (2000-02-08)
The rat subdural hematoma (SDH) model produces a zone of ischemic brain damage within the hemisphere beneath the SDH. Previous studies have measured large increases in extracellular acetylcholine during cerebral ischemia in the rat. We examined infarct volume after selectively
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