D7644
Disopyramide
Synonym(s):
α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide
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About This Item
Empirical Formula (Hill Notation):
C21H29N3O
CAS Number:
Molecular Weight:
339.47
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
223-110-2
MDL number:
InChI key
UVTNFZQICZKOEM-UHFFFAOYSA-N
InChI
1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)
SMILES string
CC(C)N(CCC(C(N)=O)(c1ccccc1)c2ccccn2)C(C)C
Gene Information
human ... CYP1A2(1544), KCNH1(3756), SCN5A(6331)
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Biochem/physiol Actions
Class IA antiarrhythmic; sodium channel blocker
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
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J P Fauchier et al.
Archives des maladies du coeur et des vaisseaux, 84(4), 553-560 (1991-04-01)
Moricizine chlorhydrate (Ethmozine), a relatively unknown antiarrhythmic agent in France, is a derivative of Phenothiazine, related to the Vaughan-Williams Class IB drugs. A randomised, double-blind, crossover trial with Disopyramide 600 mg/day after a placebo period in 10 patients with ventricular
Katsuya Kajimoto et al.
The American journal of cardiology, 106(9), 1307-1312 (2010-10-30)
Negative inotropic agents are often administered to decrease the left ventricular (LV) pressure gradient in patients with obstructive hypertrophic cardiomyopathy (HC). Little information is available regarding comparisons of the effects on LV pressure gradient among negative inotropic agents. The present
Procainamide and disopyramide.
C Ribeiro et al.
European heart journal, 8 Suppl A, 11-19 (1987-03-01)
Pharmacokinetics and pharmacodynamics of disopyramide.
J Bonde
Danish medical bulletin, 38(2), 121-133 (1991-04-01)
R N Brogden et al.
Drugs, 34(2), 151-187 (1987-08-01)
Disopyramide is a widely used class IA antiarrhythmic drug with a pharmacological profile of action similar to that of quinidine and procainamide. Over the past 10 years disopyramide has demonstrated its efficacy in ventricular and atrial arrhythmias. In therapeutic trials
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