D6135
Distamycin A hydrochloride from Streptomyces distallicus
≥90% (TLC)
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About This Item
Empirical Formula (Hill Notation):
C22H27N9O4 · HCl
CAS Number:
Molecular Weight:
517.97
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
229-505-6
MDL number:
SMILES string
Cl.Cn1cc(NC=O)cc1C(=O)Nc2cc(C(=O)Nc3cc(C(=O)NCCC(N)=N)n(C)c3)n(C)c2
assay
≥90% (TLC)
mode of action
DNA synthesis | interferes
storage temp.
−20°C
Biochem/physiol Actions
Reported to specifically inhibit the initiation of RNA synthesis.
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Danuta Drozdowska et al.
Molecules (Basel, Switzerland), 16(4), 3066-3076 (2011-04-13)
A novel and straightforward solid phase synthesis of distamycin analogues containing benzene units has been developed.
Marisol Vieites et al.
Journal of inorganic biochemistry, 105(12), 1704-1711 (2011-12-07)
In the search for drugs with anti-trypanosome activity, we had previously synthesized two series of platinum and palladium analogous compounds of the formula [M(II)Cl(2)(HL)], where HL were bioactive 5-nitrofuryl or 5-nitroacroleine thiosemicarbazone derivatives. In this work, we thoroughly characterized [M(II)Cl(2)(HL)]
Shozeb M Haider et al.
Biochimie, 93(8), 1239-1251 (2011-06-04)
This focused review article discusses in detail, all available high-resolution small molecule ligand/G-quadruplex structural data derived from crystallographic and NMR based techniques, in an attempt to understand key factors in ligand binding and to highlight the biological importance of these
Studies on the effect of distamycin A on the DNA dependent RNA polymerase system.
B Puschendorf et al.
Biochemical and biophysical research communications, 43(3), 617-624 (1971-05-07)
A N Prusov et al.
Biochemistry. Biokhimiia, 75(11), 1331-1341 (2011-02-15)
Rat liver nucleus histone H1 was fractionated by polyglutamic acid (PG) in the presence of distamycin A (DM) or chromomycin A(3) (CM). In the absence of the antibiotics, PG extracts from the nuclei about half of the nuclear H1. DM
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