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C9538

Sigma-Aldrich

Coenzyme Q10

≥98% (HPLC), powder, antioxidant

Synonym(s):

CoQ10, Q-10, Ubiquinone 50, Ubiquinone-10

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About This Item

Empirical Formula (Hill Notation):
C59H90O4
CAS Number:
303-98-0
Molecular Weight:
863.34
Beilstein:
1900141
EC Number:
206-147-9
MDL number:
MFCD00042919
UNSPSC Code:
12352200
PubChem Substance ID:
24893170
NACRES:
NA.77
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Product Name

Coenzyme Q10, ≥98% (HPLC)

Assay

≥98% (HPLC)

form

powder

color

yellow to dark orange

mp

49 °C

application(s)

cell analysis

storage temp.

−20°C

SMILES string

O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O

InChI

1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

InChI key

ACTIUHUUMQJHFO-UPTCCGCDSA-N

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1 of 4

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A9045A0701A4718
Agarose, low gelling temperature

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Agarose, low gelling temperature BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

A9045

Agarose, low gelling temperature

Agarose, low gelling temperature Type VII-A

A0701

Agarose, low gelling temperature

Agarose for molecular biology

A4718

Agarose

form

powder

form

powder

form

powder

form

powder

gel strength

≥200 g/cm2 (1% gel)

gel strength

≥200 g/cm2 (1% gel)

gel strength

≥250 g/cm2 (1% gel)

gel strength

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

transition temp

congealing temperature 26-30 °C

transition temp

congealing temperature 26-30 °C

transition temp

gel point 26 °C ±2 °C (1.5% gel)

transition temp

gel point ≤35 °C (3% gel)

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

technique(s)

electrophoresis: suitable

technique(s)

electrophoresis: suitable

General description

Coenzyme Q (CoQ), also known as ubiquinone, is a lipid-soluble antioxidant and is an essential component of the mitochondrial electron transport chain. The molecule contains a biologically active quinone with a benzoquinone ring and an isoprenoid sidechain. Q10 is synthesized in the cytoplasm and mitochondria ([1]) which generates ATP through aerobic cellular respiration. CoQ10 is required for the optimal functioning of the immune system and for cardiovascular health ([2]). The ability to repress inflammatory gene expression exhibits its anti-inflammatory property ([3] ) Genetic failure or ageing results in CoQ10 deficiency, indicated by suppression of immune function. ([1])

Application

Coenzyme Q10 (CoQ10) has been used:
  • as a bioactive compound to study its immune modulating properties in vitro[4]
  • as a standard for high-performance liquid chromatography[5][6]
  • to study its effect on exercised rat aorta[7]
  • in the cellular CoQ uptake assay[8]

Biochem/physiol Actions

Coenzyme Q10 is an endogenous cellular antioxidant and an essential component of the electron transfer chain. CoQ10 takes part in aerobic cellular respiration and generation of energy in the form of ATP.[5]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000434786
    0000434784
    0000434786
    0000434784
    0000393687

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    Francisco M Gutierrez-Mariscal et al.
    Antioxidants (Basel, Switzerland), 10(6) (2021-07-03)
    Coenzyme Q10 (CoQ10), which plays a key role in the electron transport chain by providing an adequate, efficient supply of energy, has another relevant function as an antioxidant, acting in mitochondria, other cell compartments, and plasma lipoproteins. CoQ10 deficiency is
    S Ogasahara et al.
    Neurology, 35(3), 372-377 (1985-03-01)
    In a patient with Kearns-Sayre syndrome, concentration of coenzyme Q10, a component of the mitochondrial electron transport system, was decreased in serum and in the mitochondrial fraction of skeletal muscle. Serum concentrations of lactate and pyruvate were abnormally high, especially
    Hassan Ahmadvand et al.
    ARYA atherosclerosis, 10(4), 192-198 (2014-09-27)
    Diabetes mellitus, one of the leading metabolic syndromes, accounts for highest morbidity and mortality worldwide. In this study, we examined possible protective effect of coenzyme Q10 on lipid profile, atherogenic index, and liver enzyme markers in alloxan-induced type 1 diabetic
    David Mantle et al.
    Antioxidants (Basel, Switzerland), 10(5) (2021-06-03)
    Coenzyme Q10 (CoQ10) has a number of important roles in the cell that are required for optimal functioning of the immune system. These include its essential role as an electron carrier in the mitochondrial respiratory chain, enabling the process of
    E L Appelkvist et al.
    The Clinical investigator, 71(8 Suppl), S97-102 (1993-01-01)
    Inhibitors of hydroxymethylglutaryl coenzyme A reductase are used clinically to decrease blood levels of low-density lipoprotein cholesterol in hypercholesterolemic patients. However, little is known about the possible effects of these inhibitors on dolichol and cholesterol synthesis. Oral administration of mevinolin
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