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Merck
CN

C144

1-(3-Chlorophenyl)biguanide hydrochloride

solid

Synonym(s):

1-(m-Chlorophenyl)biguanide hydrochloride, N-(3-Chlorophenyl)imidodicarbonimidic diamide hydrochloride, m-CPBG hydrochloride

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About This Item

Linear Formula:
ClC6H4NHC(NH)NHC(NH)NH2 · HCl
CAS Number:
2113-05-5
Molecular Weight:
248.11
NACRES:
NA.77
PubChem Substance ID:
24278089
UNSPSC Code:
12352202
MDL number:
MFCD00053019

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InChI

1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H

SMILES string

Cl[H].NC(=N)NC(=N)Nc1cccc(Cl)c1

InChI key

FOWAIJYHRWFTHR-UHFFFAOYSA-N

form

solid

color

white

mp

190-194 °C (lit.)

solubility

H2O: soluble

Gene Information

human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)

Biochem/physiol Actions

Very potent 5-HT3 serotonin receptor agonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCD2737
SLCB1913
SLBS8107
SLBN9992V
SLBF8520V

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Reza Rahimian et al.
Brain research, 1392, 101-109 (2011-03-31)
Tropisetron is widely used to counteract chemotherapy-induced emesis. Evidence obtained from human and animal studies shows that tropisetron possesses anti-inflammatory properties. In this study, we assessed the effect of tropisetron on brain damage in a rat thromboembolic model of stroke.
Arash Bahremand et al.
Epilepsy & behavior : E&B, 21(2), 122-127 (2011-05-03)
Citalopram, a selective serotonin reuptake inhibitor (SSRI), is frequently used in the treatment of major depressive disorders. In addition to its antidepressant features, citalopram shows some anticonvulsive properties at lower doses, whereas higher doses, ingested in cases of suicide, have
Borna Payandemehr et al.
Epilepsy research, 101(3), 217-227 (2012-05-15)
Citalopram is a selective serotonin reuptake inhibitor (SSRI), widely used in the treatment of depressive disorders. It has been shown that citalopram affects seizure susceptibility. Although the exact mechanism of these effects are not yet fully understood, recent data suggest
G J Kilpatrick et al.
European journal of pharmacology, 182(1), 193-197 (1990-06-21)
1-(m-Chlorophenyl)-biguanide (mCPBG) was examined and compared with three 5-HT3 receptor agonists in three 5-HT3 receptor models. mCPBG inhibited [3H]GR67330 binding to 5-HT3 receptors with high affinity (IC50 1.5 nM). mCPBG depolarized the rat vagus nerve with an EC50 one tenth
Wen Liu et al.
Alcohol (Fayetteville, N.Y.), 40(3), 167-176 (2007-04-10)
The objectives of the present study were to (a) examine the effects of activating serotonin-3 (5-HT3) receptors on dopamine (DA) release in the anterior and posterior ventral tegmental area (VTA) of Wistar rats and (b) determine if there are differences
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