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B7273

Sigma-Aldrich

Bezafibrate

≥98%, solid

Synonym(s):

2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid

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100 G
CN¥980.32
500 G
CN¥881.77
1 KG
CN¥1,593.12

CN¥980.32

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100 G
CN¥980.32
500 G
CN¥881.77
1 KG
CN¥1,593.12

About This Item

Empirical Formula (Hill Notation):
C19H20ClNO4
CAS Number:
41859-67-0
Molecular Weight:
361.82
EC Number:
255-567-9
MDL number:
MFCD00078970
UNSPSC Code:
12352200
PubChem Substance ID:
24891983
NACRES:
NA.77

CN¥980.32

Available to ship onApril 10, 2025Details

Request a Bulk Order

Assay

≥98%

form

solid

solubility

DMF: soluble
deionized water: insoluble
methanol: soluble

originator

Roche

SMILES string

CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O

InChI

1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)

InChI key

IIBYAHWJQTYFKB-UHFFFAOYSA-N

Gene Information

human ... HBA2(3040) , PPARA(5465) , PPARD(5467) , PPARG(5468)
mouse ... Ppara(19013) , Ppard(19015) , Pparg(19016)

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Show Differences

1 of 4

This Item
E5134ED2SS27285
乙二胺四乙酸 二钠盐 二水合物 Sigma Grade, suitable for plant cell culture, 98.5-101.5%

E6635

乙二胺四乙酸 二钠盐 二水合物

乙二胺四乙酸 二钠盐 二水合物 suitable for electrophoresis, for molecular biology, 99.0-101.0% (titration)

E5134

乙二胺四乙酸 二钠盐 二水合物

乙二胺四乙酸 二钠盐 二水合物 reagent grade, 98.5-101.5% (titration)

ED2SS

乙二胺四乙酸 二钠盐 二水合物

乙二胺四乙酸 二钠盐 二水合物 meets analytical specification of Ph. Eur., BP, USP, FCC, 99.0-101.0%

27285

乙二胺四乙酸 二钠盐 二水合物

grade

Sigma Grade

grade

for molecular biology

grade

reagent grade

grade

-

assay

98.5-101.5%

assay

99.0-101.0% (titration)

assay

98.5-101.5% (titration)

assay

99.0-101.0%

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

mp

248 °C (dec.) (lit.)

mp

248 °C (dec.) (lit.)

mp

248 °C (dec.) (lit.)

mp

248 °C (dec.) (lit.)

solubility

H2O: soluble, clear, colorless

solubility

3  M NaOH: 1.6 g/10 mL

solubility

H2O: soluble, clear, colorless

solubility

water: soluble 100 g/L at 20 °C

Application

Bezafibrate has been used:
  • a supplement in the standard diet (SD) for mice to study its effect on diabetes[1][2]
  • to evaluate its effect on hepatitis C virus (HCV) assembly and secretion[3]
  • to evaluate its effect on gonadal steroidogenesis and spermatogenesis of zebrafish and also used as standard for HPLC[4]

Biochem/physiol Actions

Bezafibrate has the ability to repress HCV assembly and secretion. It is used to treat dyslipidemia.[3]
Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid nuclear receptor superfamily. Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
PPARgamma agonists, including Bezafibrate, have beneficial effects in the suppression of the inflammatory response during RSV infection and therefore might have clinical efficacy in the course of severe RSV-infection.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    WXBF2462V
    BCCG9209
    BCCB5276
    BCCB3711
    BCBX0920

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    Magali Dumont et al.
    Human molecular genetics, 21(23), 5091-5105 (2012-08-28)
    Peroxisome proliferator-activated receptors (PPARs) are ligand-mediated transcription factors, which control both lipid and energy metabolism and inflammation pathways. PPARγ agonists are effective in the treatment of metabolic diseases and, more recently, neurodegenerative diseases, in which they show promising neuroprotective effects.
    Bezafibrate, a lipid-lowering pharmaceutical, as a potential endocrine disruptor in male zebrafish (Danio rerio)
    Velasco-Santamaria YM, et al.
    Aquatic Toxicology (Amsterdam, Netherlands), 105(1-2), 107-118 (2011)
    Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-induced diabetic mice
    Franko A, et al.
    Diabetes, 65(9), 2540-2552 (2016)
    Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice
    Franko A, et al.
    Molecular Metabolism, 6(3), 256-266 (2017)
    Marc Engelen et al.
    PloS one, 7(7), e41013-e41013 (2012-08-23)
    X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene and is characterized by impaired beta-oxidation of very-long-chain fatty acids (VLCFA) and subsequent VLCFA accumulation in tissues. In adulthood X-ALD most commonly manifests as a gradually progressive myelopathy, (adrenomyeloneuropathy;
    View All Related Papers

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