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Safety Information

B0189

Sigma-Aldrich

Casticin

from Vitex trifolia, ≥98% (HPLC)

Synonym(s):

Casticine, Quercetagetin 3,6,7,4′-tetramethyl ether, Vitexicarpin

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About This Item

Empirical Formula (Hill Notation):
C19H18O8
CAS Number:
479-91-4
Molecular Weight:
374.34
UNSPSC Code:
12352200
NACRES:
NA.25

biological source

Vitex trifolia

Assay

≥98% (HPLC)

form

powder

solubility

ethanol: 1 mg/mL, clear, colorless to light yellow

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

InChI

1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3

InChI key

PJQLSMYMOKWUJG-UHFFFAOYSA-N

General description

Casticin is one of the flavonoids present in the traditional Chinese medicine Inula japonica Thunb. It is a polymethyl compound with three rings, a catechol moiety at ortho position, one double bond, two hydroxyl groups, and four methoxy groups. It has been isolated from the fruits, seeds, and leaves of various Vitex species.

Application

Casticin from Vitex trifolia is used to study its mechanisms of action as an antiiflammatory and anticancer agent via processes such as TRAIL-induced apoptosis, cell cycle arrest, ROS generation, and glutathione (GSH) depletion.

Biochem/physiol Actions

Casticin has anticancer, pro-apoptotic, anti-proliferative, anti-asthmatic, and anti-angiogenic properties. In addition, it exhibits anti-inflammatory behavior by means of its inhibitory effect on lipoxygenases and T- & B-lymphocytes. Due to its oestrogenic activity, it is being used to manage Premenstrual syndrome in women. It is also reported to mitigate rheumatoid arthritis and liver fibrosis manifestations.
Tubulin-binding anticancer flavonoid. Casticin induces apoptosis in cancer cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBC2037V

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Lihua He et al.
Oncology reports, 29(1), 103-108 (2012-10-16)
Casticin, a polymethoxyflavone, has been reported to exert anticancer activities. The objectives of this study were to examine the molecular mechanisms by which casticin induces the growth inhibition and cell cycle arrest in human hepatocellular carcinoma (HCC) cells. The HCC
Eric Wei Chiang Chan et al.
Journal of integrative medicine, 16(3), 147-152 (2018-03-22)
This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond, two hydroxyl groups and four methoxyl groups. Casticin has been
Flavonoids from the aerial parts of Inula japonica
Qin J, et al.
Chinese Journal of Natural Medicines, 8, 257-259 (2010)
Yun Ling et al.
Biomedical chromatography : BMC, 26(12), 1502-1508 (2012-03-13)
Casticin (3',5-dihydroxy-3, 4',6,7-tetramethoxyflavone) has been revealed to possess various kinds of pharmacological activities, including immunomodulatory, anti-hyperprolactinemia, anti-tumor and neuroprotetective activities. In order to gain an understanding of the biotransformation of casticin in vivo, a systematic method based on liquid chromatography-electrospray
Jinlong Xu et al.
Journal of pharmaceutical and biomedical analysis, 61, 242-246 (2011-12-20)
A specific and sensitive liquid chromatography-mass spectrometry method has been developed and validated for identification and quantification of casticin in rat plasma after oral and intravenous administrations. Kaempferol was employed as an internal standard (IS). Liquid-liquid extraction using dichloromethane was
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