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Safety Information

A7762

Sigma-Aldrich

L-Allylglycine

≥99% (TLC), powder

Synonym(s):

(S)-(−)-2-Amino-4-pentenoic acid, L-2-Amino-4-pentenoic acid

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About This Item

Empirical Formula (Hill Notation):
C5H9NO2
CAS Number:
16338-48-0
Molecular Weight:
115.13
Beilstein:
1721512
MDL number:
MFCD00002627
UNSPSC Code:
12352200
PubChem Substance ID:
24278237

Assay

≥99% (TLC)

form

powder

optical activity

[α]25/D −37.1°, c = 4 in H2O(lit.)

color

white

solubility

H2O: 100 mg/mL

storage temp.

room temp

SMILES string

N[C@@H](CC=C)C(O)=O

InChI

1S/C5H9NO2/c1-2-3-4(6)5(7)8/h2,4H,1,3,6H2,(H,7,8)/t4-/m0/s1

InChI key

WNNNWFKQCKFSDK-BYPYZUCNSA-N

Gene Information

human ... GAD1(2571) , GAD2(2572)

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Biochem/physiol Actions

Glutamic acid decarboxylase inhibitor.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBF0768V
090M5004
018K3758
038K3732
038K3734

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J Thomas et al.
Physiology & behavior, 49(6), 1181-1183 (1991-06-01)
The possibility that a sex difference in gamma-aminobutyric acid (GABA) activity might be an underlying cause of the previously reported sex differences in picrotoxin-induced seizures was investigated. Male and female rats were injected (IP) with the GABA antagonist, L-allylglycine (100
V M Abshire et al.
Neuropharmacology, 27(11), 1171-1177 (1988-11-01)
Injection of the GABA antagonist, bicuculline methiodide into the posterior hypothalamus of rats has been shown to cause marked increases in heart rate and lesser elevations in blood pressure. Allylglycine is a potent inhibitor of the synthetic enzyme for GABA
M Bottlaender et al.
European journal of pharmacology, 321(1), 13-17 (1997-02-19)
The influence of decreased endogenous gamma-aminobutyric acid (GABA) concentration on benzodiazepine receptor function was studied in the brain of living baboons. Positron emission tomography and the radiotracer [11C]flumazenil combined with electroencephalography were used to determine the pharmacological properties of two
M Iijima et al.
British journal of pharmacology, 171(14), 3511-3525 (2014-03-25)
Vasopressin V1B receptor antagonists may be effective for the treatment of depression and anxiety and the objective of this study was to characterize the pharmacological profiles of two newly synthesized arginine vasopressin receptor 1B (V1B receptor) antagonists, TASP0233278 and TASP0390325.
Tracie A Paine et al.
Pharmacology, biochemistry, and behavior, 135, 97-104 (2015-06-06)
Cortical GABA regulates a number of cognitive functions including attention and working memory and is dysregulated in a number of psychiatric conditions. In schizophrenia for example, changes in GABA neurons [reduced expression of glutamic acid decarboxylase (GAD), parvalbumin (PV) and
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