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Safety Information

A6612

Sigma-Aldrich

Albumin human

recombinant, expressed in rice, lyophilized powder

Synonym(s):

rHSA

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About This Item

Empirical Formula (Hill Notation):
C2936H4624N786O889S41
CAS Number:
Molecular Weight:
66471.53
EC Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human

recombinant

expressed in rice

Assay

≥99% (PAGE)

form

lyophilized powder

mol wt

monomer ~67 kDa

composition

Protein, ≥90% biuret

technique(s)

cell culture | mammalian: suitable

impurities

≤6.7 EU/g Endotoxin

pH range

6.5-7.2

UniProt accession no.

storage temp.

2-8°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI key

QYSGYZVSCZSLHT-UHFFFAOYSA-N

Gene Information

human ... ALB(213)

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General description

Human serum albumin (HSA) is encoded by the gene mapped to human chromosome 4. Albumin is a globular protein with 585 amino acids. It is the most prominent protein in human sera. Albumin constitutes total concentration of about 60% of the total proteins in the blood serum. The encoded protein contains three globular domains that resemble each other in structure, each containing two subdomains. Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds.

Application

This recombinant variant is recommended for use in absorption, distribution, metabolism, and excretion (ADME) pharmacological research; cell culture; drug delivery research; and cryopreservation of cells.

Biochem/physiol Actions

Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds. Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood.
Serum albumin functions as a carrier protein for steroids, fatty acids and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood. This globular protein is broadly used to treat serious burn injuries, hemorrhagic shock, hypoproteinemia, fetal erythroblastosis and ascites caused by liver cirrhosis. HSA has various biological applications, such as carrier of oxygen, nanodelivery of drugs and fusion of peptides.

Other Notes

View more information on human serum albumin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Large-scale production of functional human serum albumin from transgenic rice seeds.
He Y, et al.
Proceedings of the National Academy of Sciences of the USA, 201109736-201109736 (2011)
Large-scale production of functional human serum albumin from transgenic rice seeds.
He Y, et al.
Proceedings of the National Academy of Sciences of the USA, 201109736-201109736 (2011)
Hung X Nguyen et al.
Nature communications, 13(1), 620-620 (2022-02-04)
Therapies for cardiac arrhythmias could greatly benefit from approaches to enhance electrical excitability and action potential conduction in the heart by stably overexpressing mammalian voltage-gated sodium channels. However, the large size of these channels precludes their incorporation into therapeutic viral
Ilya Y Shadrin et al.
Nature communications, 8(1), 1825-1825 (2017-12-01)
Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling studies, methods to generate large, functional heart tissues for human therapy are lacking. Here we present a "Cardiopatch" platform for 3D culture and
The three recombinant domains of human serum albumin structural characterization and ligand binding properties.
Dockal M, et al.
The Journal of Biological Chemistry, 274(41), 29303-29310 (1999)

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