G007
Guvacine hydrochloride
≥97% (NMR), solid
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About This Item
Empirical Formula (Hill Notation):
C6H9NO2 · HCl
CAS Number:
Molecular Weight:
163.60
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C6H9NO2.ClH/c8-6(9)5-2-1-3-7-4-5;/h2,7H,1,3-4H2,(H,8,9);1H
SMILES string
Cl.OC(=O)C1=CCCNC1
InChI key
FGNUNVVTHHKDAM-UHFFFAOYSA-N
assay
≥97% (NMR)
form
solid
color
white
solubility
H2O: soluble, ethanol: slightly soluble
Quality Level
Gene Information
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Biochem/physiol Actions
GABA uptake inhibitor.
Features and Benefits
This compound is featured on the GABA Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Solutions may be stored for several days at 4 °C.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake.
G A Johnston et al.
Nature, 258(5536), 627-628 (1975-12-18)
C Rovira et al.
Neuroscience, 12(2), 543-555 (1984-06-01)
In rats under urethane anaesthesia gamma-aminobutyric acid agonists and uptake blockers were microiontophoretically applied in the pyramidal layer of CA1 and in the apical dendrites using a twin set of multibarrelled micropipettes. Thus, the somatic and dendritic field potentials elicited
Xinran Xiang et al.
PloS one, 6(1), e14640-e14640 (2011-02-10)
Tumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates. Tumor microenvironments, however, are difficult to study in vitro. Cells cultured as monolayers exhibit less resistance to therapy than those grown in vivo and an alternative research model more
Ryan B Griggs et al.
Neuroreport, 26(9), 522-527 (2015-05-27)
Gabapentin reduces behavioral signs of stimulus-evoked allodynia and hyperalgesia in preclinical studies of traumatic nerve injury, but its effects on more clinically relevant measures of stimulus-independent pain are unclear. To address this gap, we determined whether gabapentin would relieve affective
D N Krause et al.
Brain research, 225(2), 319-332 (1981-11-30)
The interaction of GABA (gamma-aminobutyric acid) and structurally-related compounds with postsynaptic GABA receptors was studied quantitatively by measuring receptor-mediated increases in membrane input conductance in isolated crayfish stretch receptor neurons (SRN). The following compounds, in order of decreasing potency, were
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