64255
Methylenediphosphonic acid
for molecular studies & mass spectrometry
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Synonym(s):
MDP, Medronic acid
Linear Formula:
CH2[P(O)(OH)2]2
CAS Number:
Molecular Weight:
176.00
Beilstein:
1708494
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.52
Recommended Products
Quality Level
form
powder
mp
197-199 °C (lit.)
201-205 °C
storage temp.
2-8°C
SMILES string
OP(O)(=O)CP(O)(O)=O
InChI
1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)
InChI key
MBKDYNNUVRNNRF-UHFFFAOYSA-N
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General description
MDP (Methylenediphosphonic acid) is a phosphonic analog of ATP.
Application
Suitable for
- preparation of analogs of natural di- and tri-phosphates
- mass spectrometry studies as analytical standard
- molecular studies related to inflammation
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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H F Kung et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 19(9), 1027-1031 (1978-09-01)
Bidentate monophosphates--phosphonoacetate (PAA), 2-phosphonoproprionate (PPA), 2-methyl-2-phosphonoproprionate (MPPA), and carbamyl phosphate (CAP)--which are pyrophosphate analogs, were successfully labeled with Sn(II)-reduced [99mTc] pertechnetate in high yield (greater than 95%). Biodistribution studies show that these Tc-99m-labeled monophosphates do localize in bone. At 2
Phosphonic acid analogs of nucleoside phosphates. I. The synthesis of 5'-adenylyl methylenediphosphonate, a phosphonic acid analog of ATP
Myers TC et al
Journal of the American Chemical Society, 85, 3292-3295 (1963)
T G Rudd et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 18(9), 872-876 (1977-09-01)
The biologic and imaging characteristics of Tc-99m MDP and Tc-99m PPi were compared in animals and patients using freeze-dried bone-imaging kits. Biodistribution data in rabbits showed Tc-99m MDP had slightly higher bone uptake, significantly lower blood levels, and faster urinary
R. Engel
Chemical Reviews, 77, 349-349 (1977)
J.A. Stock
The Journal of Organic Chemistry, 44, 3997-3997 (1979)
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