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Merck
CN

17928

Sigma-Aldrich

O-Methyl-O′-succinylpolyethylene glycol 2′000

Synonym(s):

Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 2′000, Polyethylene glycol 2′000 monomethyl ether succinate

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25 G
CN¥927.94

CN¥927.94


Available to ship onApril 27, 2025Details


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25 G
CN¥927.94

About This Item

Linear Formula:
CH3O(CH2CH2O)nCOCH2CH2COOH
CAS Number:
MDL number:
UNSPSC Code:
51171641
NACRES:
NA.26

CN¥927.94


Available to ship onApril 27, 2025Details


Request a Bulk Order

form

powder

Quality Level

mol wt

Mr ~2100

mp

50-53 °C

Ω-end

carboxylic acid

α-end

methoxy

storage temp.

−20°C

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This Item
864774959886473
assay

≥95.0% (sum of enantiomers, GC)

assay

≥98.0% (sum of enantiomers, GC)

assay

≥95.0% (sum of enantiomers, GC)

assay

≥95.0% (GC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

density

0.934 g/mL at 20 °C

density

0.933 g/mL at 20 °C (lit.)

density

0.934 g/mL at 20 °C

density

0.837 g/mL at 25 °C (lit.)

refractive index

n20/D 1.479

refractive index

n20/D 1.479

refractive index

-

refractive index

n20/D 1.478 (lit.)

optical activity

[α]20/D -25±6°, neat

optical activity

-

optical activity

[α]/D -25±6°, neat

optical activity

-

optical purity

enantiomeric ratio: ~2:1

optical purity

enantiomeric ratio: ~2:1

optical purity

enantiomeric ratio: ~2:1

optical purity

-

Application

Polyethylene glycol 2000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Biochem/physiol Actions

O-Methyl-O′-succinylpolyethylene glycol 2′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Gulam Mustafa Hasan et al.
Journal of parasitology research, 2011, 120462-120462 (2011-07-21)
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Antitumor effect of liposomal histone deacetylase inhibitor-lipid conjugates in vitro.
Hattori Y, Nagaoka Y, Kubo M, et al.
Chemical & Pharmaceutical Bulletin, 59, 1389-1392 (2011)
Peter M Fischer et al.
Journal of peptide science : an official publication of the European Peptide Society, 8(9), 529-542 (2002-10-10)
Stepwise synthetic assembly of polypeptide chains reversibly linked to polyethylene glycol represents a hybrid between traditional solution and solid-phase chemistries and combines the inherent advantages of both approaches. The technical simplicity and scalability of the liquid-phase peptide synthesis method renders
Peptide/protein-polymer conjugates: synthetic strategies and design concepts.
Gauthier MA, Klok HA.
Chemical Communications (Cambridge, England), 21, 2591-2611 (2008)
M Z Atassi et al.
Journal of protein chemistry, 10(6), 623-627 (1991-12-01)
Recent studies from this laboratory showed that tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens. This paper describes the procedure for synthesis of well-defined conjugates of

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