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15759

Sigma-Aldrich

Poloxamer 188

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68

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10 MG
CN¥1,606.86

CN¥1,606.86

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10 MG
CN¥1,606.86

About This Item

CAS Number:
9003-11-6
MDL number:
MFCD00082049
UNSPSC Code:
12352104
NACRES:
NA.25

CN¥1,606.86

Please contact Customer Service for Availability
Request a Bulk Order

form

solid

mol wt

~7680-9510 g/mol

composition

oxyethylene, 79.9-83.7%

impurities

≤0.25% ethylene glycol and diethylene glycol
≤0.4% total ash
≤1 ppm ethylene oxide
≤1.0% water
≤2 ppm arsenic traces
≤20 ppm heavy metals
≤5 ppm dioxan
≤5 ppm propylene oxide
50-150 ppm butylhydroxytoluene

ign. residue

≤0.30%

color

APHA: ≤120, 50/50 in CH3OH

pH

5.0-7.5 (100 g/L in H2O)
6.0-7.5 (25 g/L in H2O)

CMC

0.48 mM

transition temp

cloud point >100 °C

HLB

>24

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Goat Anti-Human IgE Antibody

Goat Anti-Mouse IgG Antibody 2 mg/mL, Chemicon®

AP124

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Goat Anti-Mouse IgM Antibody Chemicon®, from goat

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Goat Anti-Mouse IgM Antibody

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

species reactivity

human

species reactivity

human

species reactivity

mouse

species reactivity

mouse

technique(s)

ELISA: suitable, western blot: suitable, immunoprecipitation (IP): suitable

technique(s)

ELISA: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

ELISA: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

ELISA: suitable, immunoprecipitation (IP): suitable, western blot: suitable

antibody form

affinity purified immunoglobulin

antibody form

affinity purified immunoglobulin

antibody form

affinity purified immunoglobulin

antibody form

F(ab′)2 fragment of affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

Application


  • Stabilizing Function of P 188 in Dermal Formulations: Examined for its stabilizing effects on industrial concentrates of dermal hesperidin smartCrystals, P 188 contributed to enhancing the long-term stability of the formulations, relevant for dermal therapeutic interventions (Romero et al., 2015).

Biochem/physiol Actions

Poloxamer 188 is widely used as a thickening agent and gel binder.

Other Notes

The Poloxamer 188 grades are poloxamers from the extensive line of block copolymers.

Legal Information

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCN0958
    BCCL8783
    BCCM5491
    BCCL3457
    BCCK4825

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    Céline Durand-Gasselin et al.
    Langmuir : the ACS journal of surfaces and colloids, 27(20), 12329-12335 (2011-09-29)
    Aggregation of thermosensitive polymer-coated gold nanoparticles was performed in aqueous solution in the presence of a triblock copolymer poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic P123, PEO(20)-PPO(68)-PEO(20)). The gold nanoparticles, AuNPs, which are covered by thermosensitive statistical copolymers poly(EO(x)-st-PO(y)), aggregate when the
    Wei Xu et al.
    Drug delivery, 19(4), 208-219 (2012-05-31)
    The aim of this study was to construct novel targeting polymeric micelles. Folate-Poly (ethylenimine)-Pluronic copolymers were synthesized. A paclitaxel (PTX)-loaded mixed micelles consisting of Folate-Poly (ethylenimine)-Pluronic and Pluronic L121 copolymers have been developed. The mixed micelles showed nano-sized spherical morphology.
    Liyan Zhao et al.
    Colloids and surfaces. B, Biointerfaces, 97, 101-108 (2012-05-23)
    In this study, curcumin (Cur) loaded mixed micelles (Cur-PF), composed of Pluronic P123 (P123) and Pluronic F68 (F68), was prepared using the thin-film hydration method and evaluated in vitro. The preparation process was optimized with a central composite design (CCD).
    Tsz Chung Lai et al.
    Colloids and surfaces. B, Biointerfaces, 99, 27-37 (2011-10-18)
    Polyplex particles formed with plasmid DNA (pDNA) and Pluronic P85-block-poly{N-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} (P85-b-P[Asp(DET)]) demonstrated highly effective transfection ability compared to PEG-based block cationomer, PEG-b-P[Asp(DET)]. Ternary polyplexes comprising PEG-b-P[Asp(DET)], poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-P[Asp(DET)] (P(EPE)-b-P[Asp(DET)]) used as an analog of P85-b-P[Asp(DET)], and pDNA were
    D J Bartley et al.
    Veterinary parasitology, 187(3-4), 464-472 (2012-03-21)
    Non-specific mechanisms involving ATP-binding cassette drug efflux transporters may play an important role in xenobiotic clearance in ovine gastro-intestinal nematodes. By using transporter inhibitors, the aim of this trial was to assess the possibility of increasing drug bioavailability in the
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