P5556
Poloxamer 188 solution
10%, sterile-filtered, BioReagent, suitable for insect cell culture
Synonym(s):
Nonionic copolymer surfactant
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12161902
PubChem Substance ID:
NACRES:
NA.75
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description
non-ionic
Quality Level
sterility
sterile-filtered
product line
BioReagent
mol wt
average mol wt 8350
concentration
10%
technique(s)
cell culture | insect: suitable
impurities
endotoxin, tested
transition temp
cloud point ≥100
HLB
29
SMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
General description
Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer. It comprises a central chain of hydrophobic polyoxypropylene flanked at ends by hydrophilic polyoxyethylene.
Application
A nonionic copolymer surfactant
Biochem/physiol Actions
Poloxamer 188 (P188) elicits hemorheological, antithrombotic, anti-inflammatory, and cytoprotective activities. It restores and stabilizes membrane barrier function. P188 also inhibits lipid peroxidation, reduces surface tension and hydrophobic-based cellular adherence. P-188 exhibits low toxicity and may be used in oral drug delivery.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Multi-walled carbon nanotubes can be divided into two general subtypes: tangled and straight. MWCNT-N (60 nm in diameter) and MWCNT-7 (80-90 nm in diameter) are straight-type MWCNTs, and similarly to asbestos, both are carcinogenic to the lung and pleura when administered to
Mimi R Borrelli et al.
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Breast capsular contracture is a major problem following implant-based breast reconstruction, particularly in the setting of radiation therapy. Recent work has identified a fibrogenic fibroblast subpopulation characterized by CD26 surface marker expression. This work aimed to investigate the role of
Martin Emanuele et al.
Drugs in R&D, 14(2), 73-83 (2014-04-12)
Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer with hemorheologic, antithrombotic, anti-inflammatory, and cytoprotective properties. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis.
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In vitro erythroid cultures from human hematopoietic stem cells produce immature red blood cells (RBCs) called reticulocytes, which are important for RBCs production, and are widely used in scientific studies of malaria pathology, hematological diseases and protein translation. However, in
Rahul P Bakshi et al.
Nature communications, 9(1), 315-315 (2018-01-24)
Chemoprophylaxis is currently the best available prevention from malaria, but its efficacy is compromised by non-adherence to medication. Here we develop a long-acting injectable formulation of atovaquone solid drug nanoparticles that confers long-lived prophylaxis against Plasmodium berghei ANKA malaria in
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