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PHR1060

Mesalamine

Name: Mesalamine
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

5-Aminosalicylic acid, 5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine

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About This Item

Linear Formula:

H₂NC₆H₃-2-(OH)CO₂H

CAS Number:

89-57-6

Molecular Weight:

153.14

Beilstein:

2090421

EC Number:

201-919-1

MDL number:

MFCD00007877

UNSPSC Code:

41116107

PubChem Substance ID:

329823090

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 1075
traceable to Ph. Eur. Y0000297
traceable to USP 1392705

API family

mesalamine, mesalazine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

275-280 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Nc1ccc(O)c(c1)C(O)=O

InChI

1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)

InChI key

KBOPZPXVLCULAV-UHFFFAOYSA-N

Gene Information

human ... ALOX5(240) , PPARG(5468) , PTGS1(5742) , PTGS2(5743)

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

Mesalamine is a drug, which is structurally similar to salicylates. It exhibits anti-inflammatory activity and is widely used as a medication for the treatment of inflammatory bowel disease, including ulcerative proctitis and Crohn′s disease.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Mesalamine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7173 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H315,H317,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 2

Flash Point(F)

No data available

Flash Point(C)

No data available

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Spectrophotometric methods for the determination of mesalamine in bulk and pharmaceutical dosage forms

Acharjya KS, et al.

Journal of Pharmaceutical Education and Research, 1(1), 63-63 (2010)

Development and validation of UV spectrophotometric method for the determination of mesalamine in bulk and tablet formulation

Moharana KA, et al.

International Journal of Pharmacy and Pharmaceutical Sciences, 3(2), 19-21 (2011)

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