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P5413

Sigma-Aldrich

Poly(ethylene glycol)

for molecular biology, average mol wt 8,000

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Synonym(s):
Poly (ethylene oxide), Polyethylene glycol, PEG
Linear Formula:
H(OCH2CH2)nOH
CAS Number:
25322-68-3
MDL number:
MFCD00081839
UNSPSC Code:
12352104
PubChem Substance ID:
24898639
NACRES:
NA.31

grade

for molecular biology

Quality Level

300

form

powder

mol wt

average mol wt 8,000

solubility

water: soluble (approximately 630 mg/ml, 20 °C)

density

1.0845 g/mL at 70 °C
1.0689 g/mL at 90 °C

foreign activity

DNase, RNase and NICKase, none detected

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Polyethylene glycol (PEG) is a polymer of ethylene oxide and water, obtained upon condensation. PEGs are susceptible to oxidative degradation in the presence of air. Minimizing the exposure of PEG to elevated temperatures and/or exposure to oxygen or addition of an antioxidant can limit the amount of degradation. PEGs do not hydrolyze or deteriorate upon storage. PEGs do not support the growth of molds.
Polyethylene glycol (PEG) is used in detergents, emulsifying agents, soaps, metal costing process, pharmaceutical preparations and cosmetics. PEG is commonly used as a lubricant. It′s application is also observed in chromatographic stationary phases. PEG prevents crystal formation in emulsions.

Application

Poly(ethylene glycol) has been used:
  • in protoplast suspension
  • to prevent phase separation in emulsion
  • in phage tail-like particles precipitation
  • for purifying and intensifying products of polymerase chain reaction

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Retinol encapsulated into amorphous Ca2+ polyphosphate nanospheres acts synergistically in MC3T3-E1 cells
Muller Werner EG, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 93, 214-223 (2015)
Genes for the biosynthesis of the fungal polyketides hypothemycin from Hypomyces subiculosus and radicicol from Pochonia chlamydosporia
Reeves CD
Applied and Environmental Microbiology, 74(16), 5121-5129 (2008)
Induction and Purification of C. difficile Phage Tail-Like Particles
Clostridium difficile, 167-175 (2016)
John M Murray
Journal of microscopy, 267(2), 193-213 (2017-03-23)
The ability to replace genes coding for cellular proteins with DNA that codes for fluorescent protein-tagged versions opens the way to counting the number of molecules of each protein component of macromolecular assemblies in vivo by measuring fluorescence microscopically. Converting
Associations between HLA class I alleles and escape mutations in the hepatitis B virus core gene in New Zealand-resident Tongans
Abbott William GH, et al.
Journal of Virology, 84(1), 621-629 (2010)
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Related Content

Polyethylene Glycol (PEG) Selection Guide

Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications.

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