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Merck
CN

F8755

Fenbufen

analytical standard

Synonym(s):

γ-Oxo-(1,1′-biphenyl)-4-butanoic acid

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About This Item

Linear Formula:
C6H5C6H4CO(CH2)2CO2H
CAS Number:
36330-85-5
Molecular Weight:
254.28
NACRES:
NA.24
PubChem Substance ID:
329799772
UNSPSC Code:
41116107
EC Number:
252-979-0
MDL number:
MFCD00056701

Key Documents

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InChI key

ZPAKPRAICRBAOD-UHFFFAOYSA-N

InChI

1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)

SMILES string

OC(=O)CCC(=O)c1ccc(cc1)-c2ccccc2

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

184-187 °C (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

100

Gene Information

human ... MMP2(4313), MMP3(4314), MMP9(4318)

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General description

Fenbufen belongs to the class of non-steroidal anti-inflammatory drugs, widely used as an antipyretic and analgesic in medical applications. Its mode of action involves the inhibition of cyclooxygenase enzyme and thereby prevents the synthesis of certain prostaglandins.

Application

Fenbufen may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

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Y Hara et al.
The Journal of veterinary medical science, 59(10), 911-915 (1997-11-15)
Effects of central nervous stimulants on the spino-bulbo-spinal reflex potential were evaluated in anesthetized intact cats, and compared with those on segmental spinal reflex potentials in anesthetized spinal cats. In spinal cats, strychnine augmented polysynaptic reflex potential, picrotoxin inhibited dorsal
F Kamali et al.
Antimicrobial agents and chemotherapy, 42(5), 1256-1258 (1998-05-21)
The potential effects of concurrent administration of fenbufen and ciprofloxacin on central nervous system activity in healthy young subjects were investigated by electroencephalography (EEG). Visual analog scales (VAS) were used to assess subjective measures of concentration, vigilance, tension, and irritability.
Kun-I Lin et al.
Molecules (Basel, Switzerland), 15(12), 8796-8803 (2010-12-04)
The previous discoveries of butyl fenbufen amide analogs with antitumor effects were further examined. The amide analogs with 1, 3, 4 and 8 carbons chains were prepared in 70-80% yield. Fenbufen had no cytotoxic effects at concentrations ranging from 10
Huarong Zhang et al.
European journal of mass spectrometry (Chichester, England), 12(5), 291-299 (2007-04-04)
The inclusion complexes of four ligands binding to cyclodextrins (CDs) were studied by electrospray ionization mass spectrometry (ESI-MS) and the dissociation constants of the complexes were obtained. The 1:1 stoichiometric inclusion complex was found in the system of CD and
Arkadiusz Pomykalski et al.
Acta poloniae pharmaceutica, 62(3), 171-176 (2005-10-01)
A methods for the determination of fenbufen and ketoprofen in pharmaceuticals by classical spectrophotometry--zero order derivative, first and second order derivatives spectrophotometry is described. using "peak-peak" (P-P) and, "peak-zero" (P-O) measurements. The calibration curves are linear within the concentration range
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