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F8755

Supelco

Fenbufen

analytical standard

Synonym(s):

γ-Oxo-(1,1′-biphenyl)-4-butanoic acid

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About This Item

Linear Formula:
C6H5C6H4CO(CH2)2CO2H
CAS Number:
36330-85-5
Molecular Weight:
254.28
EC Number:
252-979-0
MDL number:
MFCD00056701
UNSPSC Code:
41116107
PubChem Substance ID:
329799772
NACRES:
NA.24

grade

analytical standard

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

184-187 °C (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

OC(=O)CCC(=O)c1ccc(cc1)-c2ccccc2

InChI

1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)

InChI key

ZPAKPRAICRBAOD-UHFFFAOYSA-N

Gene Information

human ... MMP2(4313) , MMP3(4314) , MMP9(4318)

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General description

Fenbufen belongs to the class of non-steroidal anti-inflammatory drugs, widely used as an antipyretic and analgesic in medical applications. Its mode of action involves the inhibition of cyclooxygenase enzyme and thereby prevents the synthesis of certain prostaglandins.

Application

Fenbufen may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
048F0508

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Yue Yang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 101, 119-126 (2012-10-27)
This paper examines the comparative performance of different density functional theory (DFT) methods at various basis sets in predicting molecular and vibration spectra of gamma-oxo-[1,1'-biphenyl]-4-butanoic acid (fenbufen). DFT methods including mPW1PW91, HCTH, SVWN, PBEPBE, B3PW91 and B3LYP were investigated. Different
Interstitial nephritis, toxic epidermal necrolysis and liver dysfunction associated to fenbufen.
N Krivoy et al.
Clinical rheumatology, 16(5), 489-490 (1997-11-05)
I Bratu et al.
Biopolymers, 77(6), 361-367 (2005-02-04)
1H-NMR spectra of aqueous solutions of fenbufen and two cyclodextrins (alpha- or gamma-cyclodextrin, respectively) mixtures confirm the formation of an inclusion complex if gamma-cyclodextrin is used, whereas in the case of alpha-cyclodextrin no inclusion complex was obtained. The stoichiometry of
Bingxin Li et al.
International journal of pharmaceutics, 287(1-2), 89-95 (2004-11-16)
Layered double hydroxides (LDHs) or so-called anionic clays consist of cationic brucite-like layers and exchangeable interlayer anions. Because of their biocompatibility, these layered inorganic solids can be used as host materials to create drug-LDH host-guest supramolecular structures. Because of the
Z X Meng et al.
Colloids and surfaces. B, Biointerfaces, 84(1), 97-102 (2011-01-14)
Drug (Fenbufen, FBF)-loaded poly(D,L-lactide-co-glycolide) (PLGA) and PLGA/gelatin nanofibrous scaffolds were fabricated via electrospinning technique. The influences of gelatin content, fiber arrangement, crosslinking time and pH value of the buffer solution on FBF release behavior of the resulting nanofibrous scaffolds were
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