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Dimethyl isosorbide

Name: Dimethyl isosorbide
Brand: SIAL

BioRenewable, anhydrous, DMF and NMP substitute, ≥99%

Synonym(s):

Isosorbide dimethyl ether, 1,4:3,6-Dianhydrosorbitol 2,5-dimethyl ether, 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol, 2,5-Di-O-methyl-1,4:3,6-dianhydro-D-glucitol, DMI

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₄O₄

CAS Number:

5306-85-4

Molecular Weight:

174.19

Beilstein:

80854

MDL number:

MFCD00064828

UNSPSC Code:

12352005

NACRES:

NA.21

Quality Level

200

Assay

≥99%

form

liquid

greener alternative product characteristics

Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

color

colorless

refractive index

n20/D 1.461 (lit.)

bp

93-95 °C/0.1 mmHg (lit.)

density

1.15 g/mL at 25 °C (lit.)

greener alternative category

Aligned,

SMILES string

CO[C@H]1COC2[C@@H](COC12)OC

InChI

1S/C8H14O4/c1-9-5-3-11-8-6(10-2)4-12-7(5)8/h5-8H,3-4H2,1-2H3/t5-,6+,7-,8-/m1/s1

InChI key

MEJYDZQQVZJMPP-ULAWRXDQSA-N

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General description

We are dedicated to providing Greener Alternative Products that adhere to The 12 Principles of Greener Chemistry. Dimethyl isosorbide (DMI) is a bio-based solvent that aligns with the principles of "Use of Renewable Feedstocks" and "Safer Solvents and Auxiliaries", making it a sustainable alternative to dipolar aprotic solvents like NMP and DMF. DMI′s high solubilization capacity makes it suitable to be used as a co-solvent for nonpolar drugs and in organic synthesis. Moreover, its exceptional properties, such as non-toxicity, non-irritation, and biodegradability, make it a safe and eco-friendly choice for both customers and the environment.

Application

Polymer membranes preparation
Peptide synthesis
Cross-coupling reactions
Co-solvent to improve solubility of nonpolar compounds
Lithium battery recycling

Features and Benefits

Bio-based
Made from Renewable Resource - straw
Non-toxic solvent
Non-irritation
Biodegradability
High solubility potential

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Product No.

Description

Pricing

WGK

WGK 1

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Dimethylisosorbide (DMI) as a Bio-Derived Solvent for Pd-Catalyzed Cross-Coupling Reactions

Wilson K L, et al.

Synlett, 29, 2293-2297 (2018)

A sustainable approach to cathode delamination using a green solvent

Onurcan Buken, Kayla Mancinia and Amrita Sarkar

Royal Society of Chemistry Advances, 11, 27356-27368 (2021)

Greening Fmoc/tBu solid-phase peptide synthesis

Musaimi O A, et al.

Green Chemistry, 4, 996-1018 (2020)

Dimethyl Isosorbide As a Green Solvent for Sustainable Ultrafiltration and Microfiltration Membrane Preparation

Russo F, et al.

ACS sustainable chemistry & engineering, 8, 659?668-659?668 (2020)

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent

Mincong S, et al.

Organic Letters, 24, 354?358-354?358 (2022)