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MMYOMAG-74K

MILLIPLEX® Mouse Myokine Panel

Configurable Mouse Myokine 12-Plex Panel

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000

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Product Name

MILLIPLEX® Mouse Myokine Panel, Configurable Mouse Myokine 12-Plex Panel

species reactivity

mouse

manufacturer/tradename

Milliplex®

Quality Level

200

packaging

1 ea of

assay range

accuracy: 3-40,000 pg/mL
(Osteocrin)
standard curve range: 0.6-9,000 pg/mL
(BDNF)
standard curve range: 128-2,000,000 pg/mL
(Osteonectin (SPARC))
standard curve range: 16-250,000 pg/mL
(Oncostatin M)
standard curve range: 22-350,000 pg/mL
(EPO)
standard curve range: 256-4,000,000 pg/mL
(Myostatin)
standard curve range: 26-400,000 pg/mL
(26Irisin)
standard curve range: 3-40,000 pg/mL
(LIF)
standard curve range: 3-40,000 pg/mL
(Osteocrin/Musclin (OSTN))
standard curve range: 48-750,000 pg/mL
(IL-15)
standard curve range: 5-75,000 pg/mL
(FGF21)
standard curve range: 9-140,000 pg/mL
(IL-6)
inter-assay cv: <15%
intra-assay cv: <10%

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

General description

Skeletal muscle functions as an endocrine organ by secreting myokines—proteins that regulate muscle growth, metabolism, and inter-organ communication. This panel—BDNF, Erythropoietin (EPO), FGF-21, Follistatin-like Protein 1 (FSTL1), IL-6, IL-15, Irisin, LIF, Myostatin/GDF8, Oncostatin M (OSM), Osteocrin (OSTN)/Musclin, and Osteonectin/SPARC—captures key indicators of muscle activity, inflammation, and metabolic regulation. The MILLIPLEX® Mouse Myokine Panel enables multiplexed quantification of these biomarkers in mouse serum or plasma, supporting research in exercise physiology, metabolic disease, and muscle biology.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 12 analytes in mouse serum, plasma, or cell culture supernatants.

Analytes Included: Brain Derived Neurotrophic Factor (BDNF), Erythropoietin (EPO), Fibroblast Growth Factor 21 (FGF-21), Follistatin-like Protein 1 (FSTL1), IL-6, IL-15, Irisin, Leukemia Inhibitory Factor (LIF), Myostatin (MSTN/GDF8), Oncostatin M (OSM), Osteocrin (OSTN/Musclin), Osteonectin (SPARC) Note: Substantial amounts of BDNF are stored in circulating platelets and subsequently released upon platelet activation. Therefore, platelet-poor plasma is critical to ensure accurate measurement of circulating levels of BDNF. Erythropoeitin (EPO) is for tissue culture samples only and cannot be combined with other analytes in this panel when measuring serum or plasma.

Assay Characteristics: Refer to assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Features:

  • Targets myokines involved in muscle growth, metabolism, inflammation, and inter-organ communication
  • Includes 12 analytes relevant to skeletal muscle physiology and systemic metabolic regulation
  • Multiplex format enables simultaneous detection from minimal sample volume
  • Compatible with mouse serum, plasma, and cell/tissue culture supernatants
  • Designed for research in exercise physiology, metabolic disorders, and muscle regeneration
Benefits:

  • Provides a comprehensive profile of myokines for studying muscle-derived signaling
  • Supports investigation of exercise-induced metabolic and immune responses
  • Facilitates evaluation of therapeutic interventions in obesity, diabetes, and sarcopenia
  • Enables high-throughput analysis with reduced sample and reagent use
  • Delivers reproducible, sensitive results for preclinical and translational research

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

wgk

WGK 3

Regulatory Information

新产品
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Sofia Garcia et al.
Aging cell, 17(2) (2018-02-11)
PGC-1α is a transcriptional co-activator known as the master regulator of mitochondrial biogenesis. Its control of metabolism has been suggested to exert critical influence in the aging process. We have aged mice overexpressing PGC-1α in skeletal muscle to determine whether
Edward O List et al.
Endocrinology, 160(1), 68-80 (2018-11-22)
Global GH receptor-null or knockout (GHRKO) mice have been extensively studied owing to their unique phenotype (dwarf and obese but remarkably insulin sensitive and long-lived). To better understand the influence of adipose tissue (AT) on the GHRKO phenotype, we previously
Lars Karlsson et al.
Molecular neurobiology, 58(4), 1465-1481 (2020-11-18)
Physical exercise can improve age-dependent decline in cognition, which in rodent is partly mediated by restoration of an age-dependent decline in neurogenesis. Exercise-inducible myokines in the circulation present a link in muscle-brain crosstalk. The transcription factor PGC-1α regulates the release
Susana Peralta et al.
Journal of cell science, 131(13) (2018-06-15)
Mutations in the mitochondrial inner membrane ATPase ATAD3A result in neurological syndromes in humans. In mice, the ubiquitous disruption of Atad3 (also known as Atad3a) was embryonic lethal, but a skeletal muscle-specific conditional knockout (KO) was viable. At birth, ATAD3
Lars Karlsson et al.
Scientific reports, 9(1), 12320-12320 (2019-08-25)
Aerobic exercise prevents age-dependent decline in cognition and hippocampal neurogenesis. The transcription factor peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) mediates many of the exercise-induced benefits in skeletal muscle, including the release of factors into the circulation with neurotrophic effects.
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Quality Control Range Sheet- MMY-106 and MMY-206
Protocol- MMYOMAG-74K
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