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MAGPMAG-24K

MILLIPLEX® Mouse Angiogenesis/Growth Factor Panel 1

Configurable Mouse Angiogenesis/Growth Factor 27-Plex Panel 1

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84
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Quality Level

species reactivity

mouse

manufacturer/tradename

Milliplex®

packaging

1 ea of

assay range

accuracy: 90-104%
standard curve range: 1-1,000 pg/mL
(Endothelin-1)

standard curve range: 137-100,000 pg/mL
(Follistatin)

standard curve range: 137-100,000 pg/mL
(HGF)

standard curve range: 137-100,000 pg/mL
(SDF-1)

standard curve range: 14-10,000 pg/mL
(IL-1b)

standard curve range: 14-10,000 pg/mL
(Leptin)

standard curve range: 14-10,000 pg/mL
(MIP-1α)

standard curve range: 14-10,000 pg/mL
(sALK-1)

standard curve range: 14-10,000 pg/mL
(sCD31/ PECAM-1)

standard curve range: 27-20,000 pg/mL
(Angiopoietin-2)

standard curve range: 27-20,000 pg/mL
(EGF)

standard curve range: 27-20,000 pg/mL
(Endoglin)

standard curve range: 27-20,000 pg/mL
(MCP-1)

standard curve range: 27-20,000 pg/mL
(VEGF-C)

standard curve range: 3-2,000 pg/mL
(PLGF-2)

standard curve range: 6-4,000 pg/mL
(TNFα)

standard curve range: 6-4,000 pg/mL
(VEGF-A)

standard curve range: 69-50,000 pg/mL
(FGF-2/FGF-basic)

standard curve range: 69-50,000 pg/mL
(Prolactin)

standard curve range: 69-50,000 pg/mL
(VEGF-D)

standard curve range: 69-50,000 pg/mL
(sFasL)

standard curve range: 7-5,000 pg/mL
(Amphiregulin)

standard curve range: 7-5,000 pg/mL
(Betacellulin)

standard curve range: 7-5,000 pg/mL
(G-CSF)

standard curve range: 7-5,000 pg/mL
(IL-17A)

standard curve range: 7-5,000 pg/mL
(IL-6)

standard curve range: 7-5,000 pg/mL
(KC/CXCL1)

technique(s)

multiplexing: suitable

input

cell culture supernatant(s)

detection method

fluorometric (Luminex xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

General description

Angiogenesis, the development of new vascular networks, is a key process in normal growth and development as well as in wound healing, with homeostasis maintained by a delicate balance of angiogenic factors and inhibitors. Consequently, insufficient, or excessive blood vessel growth underlies many diseases, including cardiovascular disease, diabetic ulcers, macular degeneration, and cancer. Angiogenesis plays a significant role in tumor growth and metastasis.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 27 analytes in mouse serum, plasma, cell culture supernatants, and cell/tissue extracts.

Analytes included: sALK-1, Amphiregulin, Angiopoietin-2, Betacellulin, sCD31/sPECAM-1, EGF, Endoglin, Endothelin-1, sFasL, FGF-2 (FGF-basic), Follistatin (FST), G-CSF, HGF, IL-1β, IL-6, IL-17A (CTLA8), KC (GRO/CINC-1/CXCL1), Leptin, MCP-1 (CCL2), MIP-1α (CCL3), Placental Growth Factor 2 (PLGF-2), Prolactin, SDF-1 (CXCL12), TNF-α, VEGF-A, VEGF-C, VEGF-D Note: Sample type must be selected when configuring this kit. Angiopeoitin-2, Betacellulin, and PECAM-1 should not be run in serum/plasma samples.

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

Multiplex Capability: Simultaneous quantification of up to 24 analytes in serum/plasma or 27 analytes in cell culture samples, including key angiogenesis and growth factors such as VEGF-A, TNFα, IL-6, FGF-2, and more.

Wide Dynamic Range: Standard curve ranges vary by analyte, covering low to high pg/mL concentrations.

Flexible Sample Types: Compatible with mouse serum, plasma, tissue/cell culture supernatants or lysates.

Supports Studies on Tumor Microenvironment: Helps investigate how hypoxia, inflammation, and cytokine signaling contribute to abnormal vascularization in tumors.

Supports Translational Research: Enables biomarker discovery in mouse models that mimic human disease, supporting translational studies in oncology, inflammation, and vascular biology.

Other Notes

Sensitivity: Refer to kit protocol for sensitivities of individual analytes.

Legal Information

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Target Organs

Respiratory Tract

Storage Class Code

10 - Combustible liquids

Regulatory Information

新产品
This item has

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Kenny Schlosser et al.
Thorax, 73(3), 248-261 (2017-09-28)
Elevated plasma levels of angiopoietin-2 (ANGPT2) have been reported in patients with acute lung injury (ALI); however, it remains unclear whether this increase contributes to, or just marks, the underlying vasculopathic inflammation and leak associated with ALI. Here we investigated
Sneha Sundaram et al.
Anticancer research, 39(4), 1729-1738 (2019-04-07)
Monocyte chemotactic protein-1 (MCP1) is a potent adipokine. This study tested the hypothesis that adipose-produced MCP1 contributes to metastasis. In a spontaneous metastasis model of Lewis lung carcinoma (LLC), male adipose MCP1-deficient (Mcp1-/-) and wild-type (WT) mice were fed the
Pier-Anne Lachance et al.
PloS one, 8(9), e76078-e76078 (2013-10-03)
During acute inflammation, functioning lymphatics are believed to reduce edema and to provide a transiting route for immune cells, but the extent at which the dermal lymphatic remodeling impacts lymphatic transport or the factors regulating these changes remains unclear. Herein
Wenjie Li et al.
Stem cells international, 2022, 8540535-8540535 (2022-06-18)
Adipose-derived stem cells (ASCs) improve the self-renewal and survival of fat grafts in breast reconstruction after oncology surgery. However, ASCs have also been found to enhance breast cancer growth, and its role in tumor proliferation remains largely elusive. Here, we
Aziza R Alrafiah
Biomedicines, 9(9) (2021-09-29)
The present study focused on secondary injury following the middle cerebral artery (MCA) occlusion in rats not linked to the MCA's feeding zone. This entity has been very rarely studied. Additionally, this study investigated the rates of expression of five

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