MADCYMAG-72K
MILLIPLEX® Mouse Adipocyte Panel
Configurable Mouse Adipocyte 7-Plex Panel
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000
Product Name
MILLIPLEX® Mouse Adipocyte Panel, Configurable Mouse Adipocyte 7-Plex Panel
species reactivity
mouse
Quality Level
packaging
pkg of 1 ea
manufacturer/tradename
Milliplex®
assay range
accuracy: 85-98%
standard curve range: 12.2-50,000 pg/mL
technique(s)
multiplexing: suitable
input
cell culture supernatant
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 7 analytes in mouse cell culture supernatants.Analytes included: Adiponectin, IL-6, Leptin, MCP-1, PAI-1 (Total), Resistin, TNF-αAssay Characteristics: Refer to assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.
Disclaimer
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Features and Benefits
Features:-• Targets key adipocyte-related biomarkers involved in metabolic regulation and inflammation• Includes analytes such as adiponectin, IL-6, leptin, MCP-1, PAI-1 (Total), resistin, and TNF-α• Enables multiplex analysis for efficient and simultaneous detection• Compatible with mouse serum, plasma, and tissue culture supernatant samples• Suitable for metabolic, obesity, and inflammation-related researchBenefits:• Facilitates comprehensive profiling of adipose tissue function and immune signaling• Supports early detection of metabolic and inflammatory imbalances in preclinical models• Enhances understanding of obesity-related cytokine activity and insulin resistance• Provides robust data for evaluating therapeutic interventions targeting adipocyte pathways
General description
Adipocyte-related biomarkers such as adiponectin, leptin, resistin, IL-6, TNF-α, MCP-1, and PAI-1 play critical roles in regulating inflammation, insulin sensitivity, and energy metabolism. Adiponectin improves insulin responsiveness, leptin controls appetite and energy expenditure, and resistin is linked to insulin resistance and inflammatory signaling. IL-6 and TNF-α are key mediators of obesity-related inflammation, while MCP-1 and PAI-1 contribute to immune cell recruitment and metabolic dysfunction. Together, these analytes offer a comprehensive view of adipose tissue activity and its impact on metabolic health.
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Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
Storage Class
10 - Combustible liquids
Regulatory Information
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Gabriela Martínez-Chacón et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(5), e21536-e21536 (2021-04-30)
Obesity is a risk factor for postmenopausal breast cancer. Obesity-related inflammation upregulates aromatase expression, the rate-limiting enzyme for estrogen synthesis, in breast adipose tissue (BAT), increasing estrogen production and cancer risk. The regulation of aromatase gene (CYP19A1) in BAT is
Nasser M Rizk et al.
Journal of inflammation research, 14, 1743-1757 (2021-05-14)
Obesity is a chronic disorder characterized by a low-grade inflammatory state and immune cell irregularities. The study aimed to follow up on the changes in the peripheral CD4+ T lymphocytes and the pro-inflammatory cytokines; IL-6, TNF-alpha, MCP-1, and IL-10 at
Clément L'Huillier et al.
Nutrients, 11(6) (2019-06-19)
During activity-based anorexia (ABA) in mice, enhanced paracellular permeability and reduced protein synthesis have been shown in the colon while the gut-brain axis has received increasing attention in the regulation of intestinal and mood disorders that frequently occur during anorexia
Adipocyte Reprogramming by the Transcriptional Coregulator GPS2 Impacts Beta Cell Insulin Secretion.
Karima Drareni et al.
Cell reports, 32(11), 108141-108141 (2020-09-17)
Glucose homeostasis is maintained through organ crosstalk that regulates secretion of insulin to keep blood glucose levels within a physiological range. In type 2 diabetes, this coordinated response is altered, leading to a deregulation of beta cell function and inadequate
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Multiplex immunoassays, such as MILLIPLEX® multiplex metabolic assays, are critical in metabolic syndrome research because they provide a full picture of the different conditions related to it, like diabetes and obesity, as well as save time and sample volume.
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