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HKI5MAG-99K

Millipore

MILLIPLEX® Human Kidney Injury Magnetic Bead Panel 5 - Toxicity Multiplex Assay

The analytes available for this multiplex kit are: α-1-Microglobulin, Collagen IV, Lipocalin-2/NGAL, Osteoactivin, TIMP-1, Uromodulin.

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84
To order a Milliplex® kit, please search for your analyte of interest.
Design And Price Your Kit

Quality Level

200

species reactivity

human

manufacturer/tradename

Milliplex®

assay range

accuracy: 62-90%
intra-assay cv: <10
sensitivity: 0.05-0.56 ng/mL
(MinDC+2SD)
standard curve range: 0.05-50 ng/mL
(Lipocalin-2/NGAL)
standard curve range: 0.05-50 ng/mL
(Uromodulin)
standard curve range: 0.10-100 ng/mL
(TIMP-1)
standard curve range: 0.20-200 ng/mL
(Osteoactivin)
standard curve range: 0.24-250 ng/mL
(α-1-Microglobulin)
standard curve range: 0.49-500 ng/mL
(Collagen IV)

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

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I1395I1646SCU0001
人白细胞介素-6 (hIL-6) recombinant (E. coli)

11138600001

人白细胞介素-6 (hIL-6)

白介素 -6 人 IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

I1395

白介素 -6 人

白细胞介素-3 人 IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

I1646

白细胞介素-3 人

白介素 -6 人 recombinant, expressed in HEK 293 cells, suitable for cell culture

SCU0001

白介素 -6 人

technique(s)

cell culture | hybridoma: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

biological source

human

biological source

human

biological source

human

biological source

human

assay

>98% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

≥97% (HPLC and SDS-PAGE)

assay

≥98% (SDS-PAGE)

Quality Level

100

Quality Level

300

Quality Level

200

Quality Level

200

form

solution

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

General description

Maintenance of physiological balance in the body is attributed in part to normal kidney function. Altered kidney function due to injury, drug toxicity or kidney failure may be life threatening. Toxicity is the leading cause of drug failure, so research is expanding in search of more sensitive, rapid methods to determine organ-specific damage as quickly as possible. Traditionally, blood urea nitrogen (BUN) and serum creatinine tests have been used to determine drug-induced damage to the kidney. These tests only detect kidney damage after it begins and do not allow for the elucidation of where in the kidney the damage has occurred. Specificity and earlier detection of kidney injury is vital, and this area of research is expanding in search of more sensitive, rapid methods for determining the specific area of damage in kidney.

The MILLIPLEX® portfolio provides valuable research assays to investigate multiple biomarkers of kidney injury in human serum and plasma samples using the Luminex® xMAP® instrument platform.

The MILLIPLEX® Human Kidney Injury Bead Panel 5 contains all the components necessary to measure the following six biomarkers in any combination using Luminex® xMAP® technology: α-1-Microglobulin, Collagen IV, Lipocalin-2/NGAL, Osteoactivin, TIMP-1, Uromodulin. The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate.

Panel Type: Toxicity

Specificity

There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.

Application

  • Analytes: α-1-Microglobulin, Collagen IV, Lipocalin-2/NGAL, Osteoactivin, TIMP-1, Uromodulin
  • Recommended Sample type: serum and plasma
  • Recommended Sample dilution: 1:75 in kit Assay Buffer. Customers should determine the optimal dilution factor for their samples. Our recommendations are based on serum and plasma samples from normal subjects
  • Assay Run Time: Overnight
  • Research Category: Inflammation & Immunology

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Packaging

Everything you need in a single kit.

Storage and Stability

Recommended storage for kit components is 2 - 8°C.

Other Notes

Please contact Technical Service for linearity of dilution.
Sensitivity: Please see kit protocol for individual assay sensitivities.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Target Organs

Respiratory Tract

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Regulatory Information

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