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437650

Sigma-Aldrich

Lipopolysaccharide

from Salmonella typhimurium, , lyophilized, iNOS stimulator, Calbiochem

Synonym(s):

Salmonella LPS, Salmonella endotoxin

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CN¥980.32
500 G
CN¥881.77
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CN¥1,593.12

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100 G
CN¥980.32
500 G
CN¥881.77
1 KG
CN¥1,593.12

About This Item

UNSPSC Code:
12352201
NACRES:
NA.77

CN¥980.32

Available to ship onApril 10, 2025Details

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Product Name

Lipopolysaccharide, Salmonella typhimurium, Stimulates the activity of inducible nitric oxide synthase.

description

RTECS - OJ0895637

Quality Level

100

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

impurities

≤2% nucleic acid
≤2% protein

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

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This Item
E5134ED2SS27285
乙二胺四乙酸 二钠盐 二水合物 Sigma Grade, suitable for plant cell culture, 98.5-101.5%

E6635

乙二胺四乙酸 二钠盐 二水合物

乙二胺四乙酸 二钠盐 二水合物 suitable for electrophoresis, for molecular biology, 99.0-101.0% (titration)

E5134

乙二胺四乙酸 二钠盐 二水合物

乙二胺四乙酸 二钠盐 二水合物 reagent grade, 98.5-101.5% (titration)

ED2SS

乙二胺四乙酸 二钠盐 二水合物

乙二胺四乙酸 二钠盐 二水合物 meets analytical specification of Ph. Eur., BP, USP, FCC, 99.0-101.0%

27285

乙二胺四乙酸 二钠盐 二水合物

grade

Sigma Grade

grade

for molecular biology

grade

reagent grade

grade

-

assay

98.5-101.5%

assay

99.0-101.0% (titration)

assay

98.5-101.5% (titration)

assay

99.0-101.0%

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

mp

248 °C (dec.) (lit.)

mp

248 °C (dec.) (lit.)

mp

248 °C (dec.) (lit.)

mp

248 °C (dec.) (lit.)

solubility

H2O: soluble, clear, colorless

solubility

3  M NaOH: 1.6 g/10 mL

solubility

H2O: soluble, clear, colorless

solubility

water: soluble 100 g/L at 20 °C

General description

Endotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define revelent pathophysiological parameters of endotoxin shock, a profound life-threatening consequence of bacterial sepsis. More recently, these bacterial products have generated intense interest due to their pluripotential immunostimulatory activity, as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cells activated by lipopolysaccharides produce a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Inducible nitric oxide synthase
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.

Other Notes

Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun.63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun.61, 5044.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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