902551
BocNH-PEG4-acid
Synonym(s):
2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid, Boc-NH-PEG4-CH2COOH
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About This Item
Empirical Formula (Hill Notation):
C15H29NO8
CAS Number:
Molecular Weight:
351.39
UNSPSC Code:
12352106
NACRES:
NA.22
form
liquid
reaction suitability
reaction type: Pegylations
reagent type: cross-linking reagent
refractive index
n/D 1.4641
density
1.1395 g/mL
functional group
Boc
amine
carboxylic acid
storage temp.
−20°C
SMILES string
OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
Related Categories
Application
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
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Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
related product
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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