All Photos(1)
Synonym(s):
2,5-Dioxopyrrolidin-1-yl 3-(prop-2-ynyloxy)propanoate, 3-(2-Propyn-1-yloxy)propanoic acid 2,5-dioxo-1-pyrrolidinyl ester, Alkyne-NHS ester, Propargyl-succinimidyl-ester
Empirical Formula (Hill Notation):
C10H11NO5
CAS Number:
Molecular Weight:
225.20
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
form
solid
Quality Level
reaction suitability
reaction type: click chemistry
reagent type: cross-linking reagent
mp
36-41 °C
functional group
NHS ester
alkyne
storage temp.
−20°C
SMILES string
C#CCOCCC(ON1C(CCC1=O)=O)=O
InChI
1S/C10H11NO5/c1-2-6-15-7-5-10(14)16-11-8(12)3-4-9(11)13/h1H,3-7H2
InChI key
WKIKHHMUNOVQLD-UHFFFAOYSA-N
Related Categories
Application
Propargyl-N-hydroxysuccinimidyl ester may be used as a tool for identifying nucleophilic ligandable hotspots by chemoproteomic approaches.
Propargyl-NHS ester is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc, with a terminal alkyne. The alkyne can be reacted with an azide containing compound or biomolecule via copper catalyzed azide-alkyne click chemistry to yield a stable triazole linkage.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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