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11373

Sigma-Aldrich

HATU

≥98.0% (CHN), for peptide synthesis

Synonym(s):

1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide

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25 MG
CN¥1,081.44

CN¥1,081.44

Estimated to ship onMay 19, 2025Details

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25 MG
CN¥1,081.44

About This Item

Empirical Formula (Hill Notation):
C10H15F6N6OP
CAS Number:
148893-10-1
Molecular Weight:
380.23
MDL number:
MFCD27957364
UNSPSC Code:
12352302
PubChem Substance ID:
57646915
NACRES:
NA.22

CN¥1,081.44

Estimated to ship onMay 19, 2025Details

Request a Bulk Order

Product Name

HATU, ≥98.0% (CHN)

Quality Level

100

Assay

≥98.0% (CHN)

form

solid

reaction suitability

reaction type: Coupling Reactions

mp

183-185 °C (lit.)
183-188 °C (dec.)

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

SMILES string

F[P-](F)(F)(F)(F)F.CN(C)[C+](N(C)C)n1n[n+]([O-])c2ncccc12

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杨梅黄素 ≥96.0% (HPLC)

70050

杨梅黄素

杨梅黄素 phyproof® Reference Substance

PHL89252

杨梅黄素

杨梅黄素 ≥96.0%, crystalline

M6760

杨梅黄素

form

solid

form

powder

form

solid

form

crystalline

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

PhytoLab

manufacturer/tradename

-

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

-

storage condition

-

Application

Reagent for:
Synthesis of Aurora A kinase inhibitors
HPLC assay to determine D- and L- acid enantiomers in human plasma
Amide bond formation reactions

Catalyst for:
Selective acylation
Selecocyclization-oxidation deselenation sequence

Other Notes

Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound;[1] Advantageous coupling reagent for solid-phase peptide synthesis[2].

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1A

Supplementary Hazards

EUH044

Storage Class Code

4.1A - Other explosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    STBL4782
    STBL1490
    STBL0066
    STBK8563
    STBK7852

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    The uronium/guanidinium Peptide coupling reagents: finally the true uronium salts.
    Louis A Carpino et al.
    Angewandte Chemie (International ed. in English), 41(3), 441-445 (2002-12-20)
    Mazen Jamous et al.
    Nuclear medicine and biology, 41(6), 464-470 (2014-05-02)
    The gastrin-releasing peptide receptor (GRPR) was shown to be expressed with high density on several types of cancers. Radiolabeled peptides for imaging and targeted radionuclide therapy have been developed. In this study, we evaluated the potential of statine-based bombesin antagonists
    L. Carpino et al.
    Journal of the Chemical Society. Chemical Communications, 201-201 (1994)
    Qingxin Chen et al.
    Journal of virology, 94(19) (2020-07-17)
    Adeno-associated virus (AAV) has proven to be a promising candidate for gene therapy due to its nonpathogenic nature, ease of production, and broad tissue tropism. However, its transduction capabilities are not optimal due to the interaction with various host factors
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    Stress granules (SGs) are membrane-less ribonucleoprotein condensates that form in response to various stress stimuli via phase separation. SGs act as a protective mechanism to cope with acute stress, but persistent SGs have cytotoxic effects that are associated with several
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