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445460

Sigma-Aldrich

HATU

97%, for peptide synthesis

Synonym(s):

1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide

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About This Item

Empirical Formula (Hill Notation):
C10H15F6N6OP
CAS Number:
148893-10-1
Molecular Weight:
380.23
MDL number:
MFCD27957364
UNSPSC Code:
12352302
PubChem Substance ID:
24868183
NACRES:
NA.22

Product Name

HATU, 97%

Assay

97%

form

solid

reaction suitability

reaction type: Coupling Reactions

mp

183-185 °C (lit.)

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

SMILES string

F[P-](F)(F)(F)(F)F.CN(C)[C+](N(C)C)n1n[n+]([O-])c2ncccc12

InChI

1S/C10H15N6O.F6P/c1-13(2)10(14(3)4)15-8-6-5-7-11-9(8)16(17)12-15;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1

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185074693976245
Atto 495 maleimide BioReagent, suitable for fluorescence

41022

Atto 495 maleimide

Atto 565 maleimide BioReagent, suitable for fluorescence

18507

Atto 565 maleimide

Fluorescein diacetate 5-maleimide suitable for fluorescence

46939

Fluorescein diacetate 5-maleimide

Sigma-Aldrich

76245

Atto 655 NHS ester

fluorescence

λex 500 nm; λem 524 nm in 0.1 M phosphate pH 7.0

fluorescence

λex 563 nm; λem 592 nm in 0.1 M phosphate pH 7.0

fluorescence

λex 492 nm; λem 520 nm in 0.1 M phosphate pH 7.0 (after derivatization with 2-mercaptoethanol and after cleavage by esterase)

fluorescence

-

form

powder

form

powder

form

solid

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

product line

BioReagent

product line

BioReagent

product line

-

product line

BioReagent

manufacturer/tradename

ATTO-TEC GmbH

manufacturer/tradename

ATTO-TEC GmbH

manufacturer/tradename

-

manufacturer/tradename

ATTO-TEC GmbH

Application

Peptide coupling reagent.[1][2][3]
Preparation of N-arylsulfonamide-linked peptides by solid-phase synthesis.[4]
Reagent for:
Synthesis of Aurora A kinase inhibitors
HPLC assay to determine D- and L- acid enantiomers in human plasma
Amide bond formation reactions

Catalyst for:
Selective acylation
Selecocyclization-oxidation deselenation sequence

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1A

Supplementary Hazards

EUH044

Storage Class Code

4.1A - Other explosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    STBL4782
    WXBF1929V
    MKCT3983
    MKCT3798
    STBL1490

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    Pept., Proceedings of the European Peptide Symposium., ed. U. Ragnarrson, 27, 272-273 (2002)
    Yi He et al.
    Organic letters, 8(12), 2483-2485 (2006-06-02)
    N-Acylsulfonamide safety-catch linkers are versatile tools in solid-phase organic synthesis because of their stability. This stability necessitates linker activation prior to compound cleavage. Here, we demonstrate that the N-acylsulfonamide group can react with a pi-allyl palladium complex and that these
    J. Prakt. Chem./Chem.-Ztg., 340, 581-583 (1998)
    Lett. Pept. Sci., 9, 119-123 (2003)
    Mazen Jamous et al.
    Nuclear medicine and biology, 41(6), 464-470 (2014-05-02)
    The gastrin-releasing peptide receptor (GRPR) was shown to be expressed with high density on several types of cancers. Radiolabeled peptides for imaging and targeted radionuclide therapy have been developed. In this study, we evaluated the potential of statine-based bombesin antagonists
    View All Related Papers

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