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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
rat, mouse, human
技术
immunocytochemistry: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CLDN1(9076)
一般描述
Claudin 1 (CLDN1) is a component of tight junctions. It is part of the transmembrane tight junction protein family. The CLDN1 gene is localized on human chromosome 3q28.
免疫原
CLDN1 antibody was raised against a 20 amino acid peptide near the carboxyl terminus of human CLDN1.
生化/生理作用
Claudin 1 (CLDN1) has a role in epithelial-mesenchymal transition. It is a sealing and tightening junctional protein. CLDN1 has been shown to be downregulated in lung adenocarcinoma. Mutations in this gene have also been linked to neonatal ichthyosis and sclerosing cholangitis.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500438.
外形
Supplied in PBS with 0.02% sodium azide.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Claudin-1 correlates with poor prognosis in lung adenocarcinoma.
Sun BS
Thoracic cancer, 7(5) (2016)
CLDN-1 promoted the epithelial to migration and mesenchymal transition (EMT) in human bronchial epithelial cells via Notch pathway.
Lv J
Molecular and Cellular Biochemistry (2017)
Claudin-1 involved in neonatal ichthyosis sclerosing cholangitis syndrome regulates hepatic paracellular permeability.
Grosse B
Hepatology (2012)
The claudins
Madhu Lal-Nag and Patrice J Morin
Genome Biology (2009)
The impact of CLAUDIN-1 on follicular thyroid carcinoma aggressiveness.
Endocrine-Related Cancer, 22(5) (2015)
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