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SAB3500438

Sigma-Aldrich

Anti-CLDN1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-CLD1, Anti-CLDN1, Anti-Claudin 1, Anti-ILVASC, Anti-SEMP1
MDL number:
MFCD02096101
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

CAG33419

UniProt accession no.

O95832

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CLDN1(9076)

General description

Claudin 1 (CLDN1) is a component of tight junctions. It is part of the transmembrane tight junction protein family. The CLDN1 gene is localized on human chromosome 3q28.

Immunogen

CLDN1 antibody was raised against a 20 amino acid peptide near the carboxyl terminus of human CLDN1.

Biochem/physiol Actions

Claudin 1 (CLDN1) has a role in epithelial-mesenchymal transition. It is a sealing and tightening junctional protein. CLDN1 has been shown to be downregulated in lung adenocarcinoma. Mutations in this gene have also been linked to neonatal ichthyosis and sclerosing cholangitis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500438.

Physical form

Supplied in PBS with 0.02% sodium azide.

recommended

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related product

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WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Claudin-1 correlates with poor prognosis in lung adenocarcinoma.
Sun BS
Thoracic cancer, 7(5) (2016)
CLDN-1 promoted the epithelial to migration and mesenchymal transition (EMT) in human bronchial epithelial cells via Notch pathway.
Lv J
Molecular and Cellular Biochemistry (2017)
Claudin-1 involved in neonatal ichthyosis sclerosing cholangitis syndrome regulates hepatic paracellular permeability.
Grosse B
Hepatology (2012)
The claudins
Madhu Lal-Nag and Patrice J Morin
Genome Biology (2009)
The impact of CLAUDIN-1 on follicular thyroid carcinoma aggressiveness.
Endocrine-Related Cancer, 22(5) (2015)

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