SAB3500285
Anti-LAMP-1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Lysosome associated membrane protein 1
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
19
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 46 kDa
species reactivity
rat, human, mouse
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LAMP1(3916)
General description
Lysosomal-associated membrane protein 1 (LAMP-1) is a type I transmembrane protein with a short cytoplasmic tail containing a lysosome-targeting signal. The gene encoding this protein is localized on human chromosome 13q34.
Immunogen
LAMP-1 antibody was raised against a 15 amino acid peptide from near the center of human LAMP-1.
Application
Anti-LAMP-1 antibody produced in rabbit has been used in Western blotting.
Biochem/physiol Actions
Lysosomal-associated membrane protein 1 (LAMP-1) functions as an intracellular receptor. It is found to be expressed in the cytoplasm of several types of tumor cells and may be involved in tumor invasion. LAMP-1 is essential for perforin trafficking to the lytic granules and motility of these lytic granules. Knockdown of this protein leads to inhibition of cytotoxicity of human natural killer cells.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500285.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Constitutive expression of a COOH-terminal leucine mutant of lysosome-associated membrane protein-1 causes its exclusive localization in low density intracellular vesicles.
Akasaki K
Journal of Biochemistry (2014)
A dynamic network of estrogen receptors
in murine lymphocytes: fine-tuning
the immune response
in murine lymphocytes: fine-tuning
the immune response
Andrea E. Schneider
Journal of Leukocyte Biology (2017)
LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity.
Krzewski K
Blood (2013)
Monosomy and ring chromosome 13 in a thyroid nodular goiter-do we underestimate its relevance in benign thyroid lesions?
Sendt W
Cancer Genetics (2012)
Karolina Gronkowska et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 57(5), 360-378 (2023-09-28)
Cancer cell multidrug resistance induced by paclitaxel contributes to the high failure rates of chemotherapy and relapse of the disease. Several mechanisms have been described that underlie the observed resistance, including the overexpression of ABCB1 (P-glycoprotein), which represents an ATP-binding
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