SAB3500285
Anti-LAMP-1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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All Photos(3)
Synonym(s):
Anti-Lysosome associated membrane protein 1
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 46 kDa
species reactivity
rat, human, mouse
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LAMP1(3916)
General description
Lysosomal-associated membrane protein 1 (LAMP-1) is a type I transmembrane protein with a short cytoplasmic tail containing a lysosome-targeting signal. The gene encoding this protein is localized on human chromosome 13q34.
Immunogen
LAMP-1 antibody was raised against a 15 amino acid peptide from near the center of human LAMP-1.
Application
Anti-LAMP-1 antibody produced in rabbit has been used in Western blotting.
Biochem/physiol Actions
Lysosomal-associated membrane protein 1 (LAMP-1) functions as an intracellular receptor. It is found to be expressed in the cytoplasm of several types of tumor cells and may be involved in tumor invasion. LAMP-1 is essential for perforin trafficking to the lytic granules and motility of these lytic granules. Knockdown of this protein leads to inhibition of cytotoxicity of human natural killer cells.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Linkage
The action of this antibody can be blocked using blocking peptide SBP3500285.
Physical form
Supplied in PBS with 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Wang Peilin et al.
Materials today. Bio, 21, 100700-100700 (2023-07-17)
Tissue infection typically results from blood transmission or the direct inoculation of bacteria following trauma. The pathogen-induced destruction of tissue prevents antibiotics from penetrating the infected site, and severe inflammation further impairs the efficacy of conventional treatment. The current study
Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas.
Jensen SS
International Journal of Clinical and Experimental Pathology (2013)
Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike.
Li S
PLoS Pathogens (2016)
Yadileiny Portilla et al.
Journal of nanobiotechnology, 20(1), 543-543 (2022-12-29)
The surface coating of iron oxide magnetic nanoparticle (MNPs) drives their intracellular trafficking and degradation in endolysosomes, as well as dictating other cellular outcomes. As such, we assessed whether MNP coatings might influence their biodistribution, their accumulation in certain organs
LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity.
Krzewski K
Blood (2013)
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