TUBA1A
tubulin, alpha 1a
别名:
B-ALPHA-1, LIS3, TUBA3
物种:
Human TUBA1A (7846), Mouse Tuba1a (22142), Rat Tuba1a (64158), Horse TUBA1A (100051840), cow TUBA1A (404053), domestic cat TUBA1A (101096902), dog TUBA1A (608147), domestic guinea pig Tuba1a (100726777)
UniProtKB ID:
基因ID:
- Human(7846) Summary: Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
- Mouse(22142) tubulin, alpha 1A
- Rat(64158) tubulin, alpha 1A
- Horse(100051840) tubulin, alpha 1a
- cow(404053) tubulin, alpha 1a
- domestic cat(101096902) tubulin, alpha 1a
- dog(608147) tubulin, alpha 1a
- domestic guinea pig(100726777) tubulin, alpha 1a
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Antibodies
货号
说明
物种反应性
应用
抗微管蛋白抗体，去酪氨酸化, Chemicon®, from rabbit,
物种反应性
human, mammals, mouse, plant, rat, sea urchin
应用
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
抗-乙酰基-α微管蛋白抗体，克隆6-11B-1, clone 6-11B-1, from mouse,
物种反应性
chlamydomonas, drosophila, bovine, human, monkey, mouse, rat-kangaroo, sea urchin
应用
dot blot
electron microscopy
immunocytochemistry
western blot
electron microscopy
immunocytochemistry
western blot
抗-α-微管蛋白抗体，克隆DM1A, clone DM1A, Upstate®, from mouse,
物种反应性
avian, bovine, guinea pig, human, mouse, pig, rat
应用
immunocytochemistry
immunofluorescence
western blot
immunofluorescence
western blot
抗微管蛋白抗体，克隆YL1/2, clone YL1/2, Chemicon®, from rat,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
抗-α-微管蛋白抗体，酪氨酸化，克隆YL1/2, clone YL 1/2, from rat,
物种反应性
bovine, chicken, human, mouse, porcine, rat, yeast
应用
ELISA
electron microscopy
immunocytochemistry
immunohistochemistry
radioimmunoassay
western blot
electron microscopy
immunocytochemistry
immunohistochemistry
radioimmunoassay
western blot
Small Molecule - Inhibitor
货号
说明
物种