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Merck
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PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

别名:
CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
物种:
Human PIK3CA (5290), Mouse Pik3ca (18706), Rat Pik3ca (170911), sheep PIK3CA (101110015), chicken PIK3CA (424971), dog PIK3CA (488084), domestic guinea pig Pik3ca (100735084), naked mole-rat Pik3ca (101711934), domestic cat PIK3CA (101097413), cow PIK3CA (282306)
UniProtKB ID:
P42336, Q14CW1, Q99762
基因ID:
  • Human(5290) Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]
  • Mouse(18706) phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
  • Rat(170911) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • sheep(101110015) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • chicken(424971) phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • dog(488084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic guinea pig(100735084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • naked mole-rat(101711934) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic cat(101097413) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • cow(282306) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

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Antibodies

货号
说明
物种反应性
应用
SAB5300225
Monoclonal Anti-PIK3CA antibody produced in mouse, clone 4F3, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
flow cytometry
immunofluorescence
western blot
SAB2701957
Anti-PIK3CA antibody produced in rabbit, ,
物种反应性
human, mouse
应用
immunofluorescence
immunohistochemistry
western blot
WH0005290M1
Monoclonal Anti-PIK3CA antibody produced in mouse, clone 3G3, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
proximity ligation assay
SAB5700234
Anti-PIK3CA antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
ZRB1712
Anti-PI-3 kinase p110α Antibody, clone 1J4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, monkey
应用
affinity binding assay
flow cytometry
immunohistochemistry
western blot

Cell Lines

货号
说明
物种
CLLS1003
DLD1 Cells PIK3CA +/-, ,
物种
human
CLLS1199
MCF10A CELLS PTEN (-/-) PIK3CA H1047R (+/-), ,
物种
human

Small Molecule - Inhibitor

货号
说明
物种
PZ0235
PF-04691502, ≥98% (HPLC),
物种
human

Kits

货号
说明
物种
33-047
PI 3-激酶3步式HTRF®检测, The PI 3-Kinase 3-Step HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format.,
物种
human
33-016
PI3-激酶 HTRF ®含量测定；384 孔, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 1 plate.,
物种
human
33-017
HTRF®磷脂酰肌醇3激酶活性测定试剂盒，1920 孔, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 5 plates.,
物种
human
33-036
PI 3-Kinase HTRF® Assay; 10,000 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 10,000 wells.,
物种
human
33-04A
PI 3-Kinase 3-step HTRF® Assay, Everything you need to perform the PI3 Kinase 3-step HTRF assays (1920 wells).,
物种
human

Proteins

货号
说明
物种
14-602-M
PI3激酶（p110α/p85α），人，活性，20 µg, Active complex of N-terminal His6-tagged recombinant full-length human p110α & untagged, recombinant, full length, human p85α. For use in Kinase Assays.,
物种
human
SRP0233
PI3 kinase (p110a/p85a) Active human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
物种
human
14-790-M
PI3 Kinase (p110α/p65α), 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length Human p110α & untagged, recombinant, full length Human p65α. For use in Kinase Assays.,
物种
human
14-783-M
PI3激酶（p110α(E545K)/p85α），10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E545K & untagged, recombinant, full-length human p85α. For use in Kinase Assays.,
物种
human
14-787-M
PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R α & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.,
物种
mouse

esiRNA

货号
说明
物种
EHU231281
MISSION® esiRNA, targeting human PIK3CA (2),
物种
human
EHU039391
MISSION® esiRNA, targeting human PIK3CA,
物种
human
EMU053821
MISSION® esiRNA, targeting mouse Pik3ca,
物种
mouse